4.7 Article

Branched-chain amino acid supplementation impairs insulin sensitivity and promotes lipogenesis during exercise in diet-induced obese mice

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Branched-chain amino acid metabolism, insulin sensitivity and liver fat response to exercise training in sedentary dysglycaemic and normoglycaemic men

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Summary: The study found that obesity and insulin resistance are associated with elevated plasma levels of BCAAs, and insulin sensitivity is correlated with BCAA levels in the body. Global mRNA-sequencing pathway analysis revealed reduced BCAA metabolism in individuals with insulin resistance compared to normal individuals at baseline. Additionally, exercise for 12 weeks was shown to increase BCAA metabolism in both groups, as indicated by enhanced expression of the gene encoding BCKDH.

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