4.7 Article

Branched-chain amino acid supplementation impairs insulin sensitivity and promotes lipogenesis during exercise in diet-induced obese mice

期刊

OBESITY
卷 30, 期 6, 页码 1205-1218

出版社

WILEY
DOI: 10.1002/oby.23394

关键词

-

资金

  1. Hong Kong Research Grants Council [SRFS2021-4S04, C4024-16W]
  2. Natural Science Foundation of China [91939302]

向作者/读者索取更多资源

Exercise reduces body weight, improves insulin sensitivity, lowers BCAAs in plasma, and inhibits the upregulation of BCAAs and metabolites caused by BCAA supplementation in the subcutaneous white adipose tissue of obese mice. BCAA supplementation reverses the improved insulin sensitivity from exercise in obese mice, but has no effect in lean mice. BCAAs also increase lipogenesis gene expression in the subcutaneous white adipose tissue of exercised obese mice.
Objective Branched-chain amino acids (BCAAs) are popular dietary supplements for exercise. However, increased BCAA levels positively correlate with obesity and diabetes. The metabolic impact of BCAA supplementation on insulin sensitivity during exercise is less understood. Methods Male C57BL/6 mice were fed for 12 weeks with a high-fat diet, normal chow diet, or BCAA-restricted high-fat diet. They were subjected to running exercise with or without BCAA treatment for another 12 weeks. Results Exercise reduced body weight, improved insulin sensitivity, lowered BCAAs in plasma, and inhibited the upregulation of BCAAs and metabolites caused by BCAA supplementation in the subcutaneous white adipose tissue (sWAT) of obese mice. BCAA supplementation reversed insulin sensitivity ameliorated by exercise. The phosphorylation of protein kinase B (Ser473 and Ser474) was decreased by BCAAs in the sWAT of obese mice. However, BCAA supplementation had no such effects in lean mice. BCAAs also increased the expression of fatty acid synthase and other lipogenesis genes in the sWAT of exercised obese mice. BCAA restriction had no effect on body weight and insulin sensitivity in obese mice. Conclusions BCAA supplementation impaired the beneficial effect of exercise on glycolipid metabolism in obese but not lean mice. Caution should be taken regarding the use of BCAAs for individuals with obesity who exercise.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据