期刊
NUCLEIC ACIDS RESEARCH
卷 50, 期 W1, 页码 W490-W499出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkac306
关键词
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资金
- Agence Nationale de la Recherche [ANR-18-CE45-0016-01]
- Fondation pour la Recherche Medicale [MND202003011460]
- Centre National de la Recherche Scientifique
- Aix-Marseille University
- Agence Nationale de la Recherche (ANR) [ANR-18-CE45-0016] Funding Source: Agence Nationale de la Recherche (ANR)
Mitochondria, subcellular organelles present in eukaryotic cells, play a central role in cellular metabolism. The upgraded version 2.0 of the mitoXplorer platform provides integrative functions and novel features to help identify regulatory factors of mitochondrial processes and facilitate data analysis.
Mitochondria are subcellular organelles present in almost all eukaryotic cells, which play a central role in cellular metabolism. Different tissues, health and age conditions are characterized by a difference in mitochondria! structure and composition. The visual data mining platform mitoXplorer 1.0 was developed to explore the expression dynamics of genes associated with mitochondrial functions that could help explain these differences. It, however, lacked functions aimed at integrating mitochondria in the cellular context and thus identifying regulators that help mitochondria adapt to cellular needs. To fill this gap, we upgraded the mitoXplorer platform to version 2.0 (mitoXplorer 2.0). In this upgrade, we implemented two novel integrative functions, network analysis and transcription factor enrichment, to specifically help identify signalling or transcriptional regulators of mitochondria! processes. In addition, we implemented several other novel functions to allow the platform to go beyond simple data visualization, such as an enrichment function for mitochondrial processes, a function to explore time-series data, the possibility to compare datasets across species and an IDconverter to help facilitate data upload. We demonstrate the usefulness of these functions in three specific use cases. mitoXplorer 2.0 is freely available without login at http://mitoxplorer2.ibdm.univ-mrs.fr. [GRAPHICS] .
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