4.6 Article

Daily adaptive proton therapy: Feasibility study of detection of tumor variations based on tomographic imaging of prompt gamma emission from proton-boron fusion reaction

期刊

NUCLEAR ENGINEERING AND TECHNOLOGY
卷 54, 期 8, 页码 3006-3016

出版社

KOREAN NUCLEAR SOC
DOI: 10.1016/j.net.2022.03.006

关键词

Proton-boron fusion reaction; Prompt gamma ray; SPECT; Adaptive proton therapy

资金

  1. National Research Foundation of Korea (NRF) - Korean government [2018R1A2B2005343, 2017M3A9E2060428]
  2. National Research Foundation of Korea [2018R1A2B2005343, 2017M3A9E2060428] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

In this study, the authors analyzed images of specific prompt gamma-rays emitted from proton-boron reactions using single-photon emission computed tomography (SPECT). Quantitative evaluation confirmed the detection of anatomical changes in tumors and the potential application of these images in daily adaptive proton therapy (DAPT).
In this study, the images of specific prompt gamma (PG)-rays of 719 keV emitted from proton-boron reactions were analyzed using single-photon emission computed tomography (SPECT). Quantitative evaluation of the images verified the detection of anatomical changes in tumors, one of the important factors in daily adaptive proton therapy (DAPT) and verified the possibility of application of the PG-ray images to DAPT. Six scenarios were considered based on various sizes and locations compared to the reference virtual tumor to observe the anatomical alterations in the virtual tumor. Subsequently, PG-rays SPECT images were acquired using the modified ordered subset expectation-maximization algorithm, and these were evaluated using quantitative analysis methods. The results confirmed that the pixel range and location of the highest value of the normalized pixel in the PG-rays SPECT image profile changed according to the size and location of the virtual tumor. Moreover, the alterations in the virtual tumor size and location in the PG-rays SPECT images were similar to the true size and location alterations set in the phantom. Based on the above results, the tumor anatomical alterations in DAPT could be adequately detected and verified through SPECT imaging using the 719 keV PG-rays acquired during treatment. (C) 2022 Korean Nuclear Society, Published by Elsevier Korea LLC.

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