期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 136, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2022.104603
关键词
Gut-brain axis; Satiety; appetite; Gut peptides; Neuroimaging; Coordinate based meta-analysis; Activation likelihood estimation (ALE); Analysis of Brain Coordinates (ABC); Obesity; Altered eating behavior
资金
- Medical Research Council [MR/K00414X/1]
- Arthritis Research UK [19891]
- King Abdulaziz University, Jeddah, Saudi Arabia
- Future Food Beacon, University of Nottingham
Understanding the regulation of appetite and satiety by neurohormonal gut-brain signaling is crucial for developing therapies for obesity and altered eating behavior. However, previous studies have shown inconsistent brain areas associated with appetite and satiety regulators. This study systematically assessed the convergence of brain regions modulated by these regulators and found differential effects on different brain areas.
Understanding how neurohormonal gut-brain signaling regulates appetite and satiety is vital for the development of therapies for obesity and altered eating behavior. However, reported brain areas associated with appetite or satiety regulators show inconsistency across functional neuroimaging studies. The aim of this study was to systematically assess the convergence of brain regions modulated by appetite and satiety regulators. Twenty-five studies were considered for qualitative synthesis, and 14 independent studies (20-experiments) found eligible for coordinate-based neuroimaging meta-analyses across 212 participants and 123 foci. We employed two different meta-analysis approaches. The results from the systematic review revealed the modulation of insula, amygdala, hippocampus, and orbitofrontal cortex (OFC) with appetite regulators, where satiety regulators were more associated with caudate nucleus, hypothalamus, thalamus, putamen, anterior cingulate cortex in addition to the insula and OFC. The two neuroimaging meta-analyses methods identified the caudate nucleus as a key area associated with satiety regulators. Our results provide quantitative brain activation maps of neurohormonal gut brain signaling in heathy-weight adults that can be used to define alterations with eating behavior.
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