期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 136, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2022.104609
关键词
Remote memory; Retrieval; Allocentric strategy; Rodents; System consolidation
资金
- Fundacion Espanola para la Ciencia y la Tecnologia (FECYT) [AYUD/2021/51378]
- Ministerios de Ciencia e Innovacion [PID2020-117259RB-I00]
- Programa Severo Ochoa de Ayudas Predoctorales de la Con-sejeria de Cultura y Deporte del Principado de Asturias [PA-18-PF-BP17-011]
Studies suggest that in rodents, normal forgetting may occur during remote spatial retrieval, involving changes in morphology and functionality of neocortical areas, hippocampus, and other brain structures. These results help us better understand the timing of memory maintenance and normal forgetting, outlining the implicated brain areas.
Successful spatial cognition involves learning, consolidation, storage, and later retrieval of a spatial memory trace. The functional contributions of specific brain areas and their interactions during retrieval of past spatial events are unclear. This systematic review collects studies about allocentric remote spatial retrieval assessed at least two weeks post-acquisition in rodents. Results including non-invasive interventions, brain lesion and inactivation experiments, pharmacological treatments, chemical agent administration, and genetic manipulations revealed that there is a normal forgetting when time-periods are close to or exceed one month. Moreover, changes in the morphology and functionality of neocortical areas, hippocampus, and other subcortical structures, such as the thalamus, have been extensively observed as a result of spatial memory retrieval. In conclusion, apart from an increasingly neocortical recruitment in remote spatial retrieval, the hippocampus seems to participate in the retrieval of fine spatial details. These results help to better understand the timing of memory maintenance and normal forgetting, outlining the underlying brain areas implicated.
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