期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 135, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2022.104579
关键词
Psychiatric disorder; Epigenetics; Epigenetic inheritance; DNA methylation; Histone modifications; NcRNAs
资金
- National Institute of Health/National Institute of Mental Health [1R21MH117636-01A1]
- John S. Dunn Foundation
- Anne and Don Fizer Foundation Endowment for Depression Research
- National Institute of Mental Health [5K01MH121580]
- American Foundation for Suicide Prevention (AFSP) [YIG-0-066-20]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Fundacao de Apoio `a Pesquisa e Inovacao do Estado de Santa Catarina (FAPESC)
- Instituto Cerebro e Mente
- Pat Rutherford Jr. Chair in Psychiatry
Epigenetics is considered as a key link between gene and environment, influencing susceptibility to psychiatric disorders. Recent evidence suggests that acquired changes can be transmitted across generations in different species, providing new insights into the transmission of psychiatric-related information.
Susceptibility to psychiatric disorders seems to be influenced by environmental disturbances throughout all stages of life. Epigenetics is described as a key bridge between gene and environment, shaping gene expression and phenotype in response to environmental influences. For a long time, it was believed the epigenetic information could not be transmitted from one generation to the next, however, recent evidence has demonstrated that these acquired changes can be transmitted across generations in different species, with implications also for humans. The emerging evidence of epigenetic inheritance mechanisms is changing the concept of how and what information can be transferred across generations, rising as a promising theory to explain how psychiatric-related information can be inherited. In this review, we will discuss the main theory about epigenetic inheritance, present clinical evidence of its potential role in major psychiatric disorders, and how studies with patients and animal models have helped describe the epigenetic mechanisms and possible targets underlying this process in schizophrenia, bipolar disorder, depression, post-traumatic stress disorder, anxiety, substance use disorder and autism.
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