Unraveling Molecular and System Processes for Fear Memory

For decades, Izquierdo and colleagues contributed to building the notion that declarative memory requires different processes at the molecular and systems levels. This review aims to discuss part of Izquierdo's legacy, mainly but not exclusively that related to fear memory. First, some of the philosophical and evolutionary issues that arise from declarative memory definition are presented. Then, the underlying processes of declarative memory are depicted, discussing the formation, the nature and the progression of the memory trace in short-term and long-term memory, and describing the involvement of some molecular cascades in the hippocampal formation, mesocortex and frontal areas. Potential contributions to therapy or understanding cognitive processes are mentioned. (C) 2022 IBRO. Published by Elsevier Ltd. All rights reserved.

Automated summary

This review discusses the contributions of Izquierdo and colleagues in the field of declarative memory, focusing on fear memory. It covers the philosophical and evolutionary issues related to declarative memory definition, and describes the underlying processes of declarative memory, including the formation and progression of memory trace in short-term and long-term memory, as well as the involvement of molecular cascades in the hippocampal formation, mesocortex, and frontal areas. The review also mentions the potential contributions of this research to therapy and understanding cognitive processes.