期刊
NEUROPSYCHOPHARMACOLOGY
卷 47, 期 10, 页码 1854-1862出版社
SPRINGERNATURE
DOI: 10.1038/s41386-022-01344-y
关键词
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资金
- Henry Wallace Foundation
- Yale University from the US National Institute of Health
- US Department of Veteran Affairs
- Takeda
- Biogen
- Boehringer Ingelheim
- Ceruvia
- Heffter Institute
- Wallace Foundation
This study explored the safety and efficacy of DMT as a treatment for depression. The results showed that DMT was tolerated by both healthy individuals and patients with treatment-resistant depression. Patients with depression experienced improved mood one day after receiving DMT. The adverse effects of DMT were mostly mild and short-lived. This study provides a foundation for further investigation into the antidepressant effects of DMT.
There is considerable interest in the therapeutic potential of psychedelic drugs. Dimethyltryptamine (DMT) is a potent, rapid-onset, and short-acting psychedelic drug that has not yet been independently tested for the treatment of depression. The safety, tolerability, and efficacy of intravenous DMT were investigated in treatment-resistant individuals with major depressive disorder (MDD) and healthy controls (HC) in an open-label, fixed-order, dose-escalation (0.1 mg/kg followed by 0.3 mg/kg) exploratory phase 1 study that was conducted in a typical hospital setting with strategic psychoeducation/support, but minimal psychotherapy. Tolerability, safety, cardiovascular function, abuse liability, psychedelic, and psychotomimetic effects, mood, and anxiety were assessed at each dosing session. In addition, depression was measured using the HAMD-17 in MDD participants 1 day after each dosing session. DMT was tolerated by both HC (n = 3) and MDD participants (n = 7) studied; there were no dropouts. HAMD-17 scores decreased significantly (p = 0.017) compared to baseline in MDD participants the day after receiving 0.3 mg/kg DMT (mean difference -4.5 points, 95% CI: -7.80 to -1.20, Hedge's g = 0.75). Adverse events were mostly mild with one self-limited serious event. DMT increased blood pressure, heart rate, anxiety, psychedelic effects, and psychotomimetic effects, which resolved within 20-30 min of injection. There were no dose-related differences in measures of drug reinforcement and abuse liability. In this small exploratory pilot study, intravenous DMT at doses of 0.1 and 0.3 mg/kg was mostly safe and tolerated and may have next-day (rapid) antidepressant effects in patients with treatment-resistant MDD. Further rigorous trials are warranted to replicate these findings and to determine the durability of antidepressant effects.
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