Why you always in a mood? Pumpin' polyP, actin' brand new

What causes neurons to die in neurodegenerative disease? In this issue of Neuron, Arredondo et al., 2022 report an unexpected culprit that may drive neuronal death in amyotrophic lateral sclerosis-an evolutionarily ancient energy-storage polymer called polyphosphate (polyP).

Automated summary

This study reveals polyphosphate (polyP) as an unexpected factor that may drive neurodegeneration by causing neuronal death in amyotrophic lateral sclerosis.