期刊
NEURON
卷 110, 期 12, 页码 2024-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2022.03.032
关键词
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资金
- EMBO [ALTF 1552-2015]
- HFSP fellowships [LT000447/2016]
- NKFIH [129120]
- MTA (Lendulet)
- DFG [118803580-SFB 870]
- SNSF Synergia [CRSII3_141801]
- SNSF [31003A_182523]
- SNSF NCCR Molecular Systems Engineering''
- ERC [669157, 883781]
- Louis-Jeantet Foundation
- Koerber Foundation
- Swiss National Science Foundation (SNF) [31003A_182523, CRSII3_141801] Funding Source: Swiss National Science Foundation (SNF)
- European Research Council (ERC) [883781, 669157] Funding Source: European Research Council (ERC)
General anesthetics induce synchronized activity in mouse layer 5 pyramidal neurons, which coincides with the loss and recovery of consciousness. This suggests that brain-wide synchrony in layer 5 pyramidal neurons may play a key role in anesthesia.
General anesthetics induce loss of consciousness, a global change in behavior. However, a corresponding global change in activity in the context of defined cortical cell types has not been identified. Here, we show that spontaneous activity of mouse layer 5 pyramidal neurons, but of no other cortical cell type, becomes consistently synchronized in vivo by different general anesthetics. This heightened neuronal synchrony is aperiodic, present across large distances, and absent in cortical neurons presynaptic to layer 5 pyramidal neurons. During the transition to and from anesthesia, changes in synchrony in layer 5 coincide with the loss and recovery of consciousness. Activity within both apical and basal dendrites is synchronous, but only basal dendrites??? activity is temporally locked to somatic activity. Given that layer 5 is a major cortical output, our results suggest that brain-wide synchrony in layer 5 pyramidal neurons may contribute to the loss of consciousness during general anesthesia.
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