期刊
NEUROMODULATION
卷 26, 期 2, 页码 394-402出版社
ELSEVIER
DOI: 10.1016/j.neurom.2022.01.004
关键词
Deep brain stimulation; depression; Parkinson disease; personality trait; total electrical energy delivered
This study investigates the impact of deep brain stimulation on personality characteristics in Parkinson's disease patients and finds that despite improvements in motor function and quality of life, there is a significant increase in depressive traits.
Objectives: Despite the large amount of literature examining the potential influence of subthalamic nucleus deep brain stim-ulation (STN-DBS) on psychiatric symptoms and cognitive disorders, only a few studies have focused on its effect on personality. We investigated the correlation between total electrical energy delivered (TEED) and the occurrence of depressive traits in patients with Parkinson disease (PD) after one year of DBS.Materials and Methods: Our study involved 20 patients with PD (12 women, mean [+/- SD] age 57.60 +/- 7.63 years) who underwent bilateral STN-DBS, whose personality characteristics were assessed using the Minnesota Multiphasic Personality Inventory-2 (MMPI-2), according to the core assessment program for surgical interventional therapies in Parkinson's disease (CAPSIT-PD) procedure.Results: We found that despite a marked improvement in motor functions and quality of life after 12 months, patients showed a significant increase in MMPI-2 subscales for depression (D scale and Depression scale) and in other content component scales (low self-esteem, work interference, and negative treatment indicators). Interestingly, only the TEED on the right side was inversely correlated with the changes in scale D (rs = -0.681, p = 0.007), whereas depressive traits did not correlate with disease duration, levodopa equivalent daily dose (LEDD) reduction, patient's age, or severity of motor symptoms.Conclusions: Our preliminary observations indicate that despite the excellent motor outcome and general improvement in quality of life, DBS treatment can result in patients poorly adjusting to their personal, familiar, and socio-professional life. Different influences and multiple factors (such as TEED, intra/postsurgical procedure, coping mechanisms, and outcome expectations) may affect depressive traits. Further advances are expected to improve stimulation methods.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据