☆ 4.7 Editorial Material

Slowly Expanding Lesions A New Target for Progressive Multiple Sclerosis Trials?

NEUROLOGY (2022)

Association of Slowly Expanding Lesions on MRI With Disability in People With Secondary Progressive Multiple Sclerosis

Alberto Calvi et al.

Summary: This study found that slowly expanding lesions (SELs) make up a significant proportion of T2 lesions in secondary progressive multiple sclerosis (SPMS). These lesions are associated with neurodegenerative MRI markers and clinical worsening, suggesting that they may contribute to disease progression and be a new target for therapeutic interventions.

NEUROLOGY (2022)

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Article Multidisciplinary Sciences

A lymphocyte-microglia-astrocyte axis in chronic active multiple sclerosis

Martina Absinta et al.

Summary: Through MRI-guided single-nucleus RNA sequencing, a diversity of glial and immune cells at the edge of demyelinated white matter lesions in multiple sclerosis (MS) have been identified, along with the definition of inflamed glial cell phenotypes in MS. The overlap of the transcriptional profile of microglia inflamed in MS with that in other neurodegenerative diseases suggests common mechanisms between primary and secondary neurodegeneration that could benefit from similar therapeutic approaches. The critical role of complement component 1q (C1q) in the activation of microglia inflamed in MS has been identified and potential therapeutic avenues, such as C1q inhibition, have been suggested for addressing chronic white matter inflammation.

NATURE (2021)

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Article Clinical Neurology