Distribution of α-Synuclein Aggregation in the Peripheral Tissues

Parkinson's disease (PD) is a chronic neurodegenerative disease mainly characterized by movement disorders and other non-motor symptoms, including the loss of dopaminergic neurons in the substantia nigra parts. Abnormal alpha-synuclein aggregation in the brain is closely associated with the loss of dopaminergic neurons. alpha-synuclein can propagate in the central nervous system (CNS) and periphery under pathological conditions. Many researches have focused on its aggregation and distribution in the CNS and explored its relationship with PD. But in recent years, the distribution of alpha-synuclein in peripheral tissues have been paid much attention. This review summarized the distribution of alpha-synuclein in the choroid plexus, blood, saliva, gastrointestine and other tissues, and discussed the potential mechanism of alpha-synuclein aggregation, providing a basis for the early diagnosis and intervention of PD.

Automated summary

This review summarizes the distribution of alpha-synuclein in the central nervous system and peripheral tissues of Parkinson's disease patients, and discusses the aggregation mechanism, providing a basis for early diagnosis and intervention.