期刊
NEUROBIOLOGY OF AGING
卷 111, 期 -, 页码 54-63出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2021.11.007
关键词
White matter hyperintensities; small-vessel disease; neurodegenerative disease; Alzheimer's disease; fronto-temporal dementia; Parkinson's disease; mild cognitive impairment
资金
- Famille Louise AndreCharron
- Canadian Consortium on Neurodegeneration in Aging
- Alzheimer Society Research Program (ASRP) postdoctoral award
- Canadian Institutes of Health Research
- Alzheimer Society of Canada
- Sanofi
- Women's Brain Health Initiative
- Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health) [U01 AG024904]
- DOD ADNI (Department of Defense) [W81XWH-12-20012]
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- AbbVie
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Araclon Biotech
- BioClinica, Inc.
- Biogen
- Bristol-Myers Squibb Company
- CereSpir, Inc.
- Cogstate
- Eisai Inc.
- Elan Pharmaceuticals, Inc.
- Eli Lilly and Company
- EuroImmun
- F. Hoffmann-La Roche Ltd.
- Genentech, Inc.
- Fujirebio
- GE Healthcare
- IXICO Ltd.
- Janssen Alzheimer Immunotherapy Research & Development, LLC.
- Johnson & Johnson Pharmaceutical Research & Development LLC.
- NeuroRx Research
- Novartis Pharmaceuticals Corporation
- Pfizer Inc.
- Piramal Imaging
- Servier
- Takeda Pharmaceutical Company
- Transition Therapeutics
- Michael J Fox Foundation for Parkinson's Research
- Avid Radiopharmaceuticals
- Bristol-Myers Squibb
- Covance
- Genentech
- GlaxoSmithKline (GSK)
- Lundbeck
- Merck
- Meso Scale Discovery (MSD)
- Pfizer
- Roche
- UCB
- Lumosity
- Merck Co., Inc.
- Meso Scale Diagnostics, LLC.
- Neurotrack Technologies
- Frontotemporal Lobar Degeneration Neuroimaging Initiative (National Institutes of Health Grant) [R01 AG032306]
White matter hyperintensities may have a synergistic effect in the neurodegenerative processes of mild cognitive impairment, Alzheimer's dementia, and fronto-temporal dementia, affecting grey matter atrophy and cognition.
White matter hyperintensities (WMHs) are commonly assumed to represent non-specific cerebrovascular disease comorbid to neurodegenerative processes, rather than playing a synergistic role. We compared the impact of WMHs on grey matter (GM) atrophy and cognition in normal aging (n = 571), mild cognitive impairment (MCI, n = 551), Alzheimer's dementia (AD, n = 212), fronto-temporal dementia (FTD, n = 125), and Parkinson's disease (PD, n = 271). Longitudinal data were obtained from ADNI, FTLDNI, and PPMI datasets. Mixed-effects models were used to compare WMHs and GM atrophy between patients and controls and assess the impact of WMHs on GM atrophy and cognition. MCI, AD, and FTD patients had significantly higher WMH loads than controls. WMHs were related to GM atrophy in insular and parieto-occipital regions in MCI/AD, and frontal regions and basal ganglia in FTD. In addition, WMHs contributed to more severe cognitive deficits in AD and FTD compared to controls, whereas their impact in MCI and PD was not significantly different from controls. These results suggest potential synergistic effects between WMHs and proteinopathies in the neurodegenerative process in MCI, AD and FTD. (C) 2021 Elsevier Inc. All rights reserved.
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