4.5 Article

Biophysical and synaptic properties of regular spiking interneurons in hippocampal area CA3 of aged rats

期刊

NEUROBIOLOGY OF AGING
卷 112, 期 -, 页码 27-38

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2021.12.007

关键词

Aging; CA3 interneuron; Biophysical properties; MF-CA3 interneuron synapse; Feed-forward inhibition; AMPA receptors

资金

  1. Conacyt (National Council of Science and Technology, Mexico) [CB-2016-281617, 727269]

向作者/读者索取更多资源

This study reveals changes in neuronal activity and AMPA receptor subunit composition in the dentate gyrus of aged animals, suggesting a potential link between these changes and age-related memory impairment.
Neuronal processing from the dentate gyrus to the hippocampus is critical for storage and recovery of new memory traces. In area CA3, GABAergic interneurons form a strong barrage of inhibition that modulates pyramidal cells. A well-established feature of aging is decreased GABAergic inhibition, a phenomenon that contributes to the exacerbated excitability of aged pyramidal cells. In hippocampal slices of aged rats (22-28 months old) we examined the properties of regular spiking CA3 interneurons with patch-clamp whole-cell recordings. We found enhanced firing discharge without altering the maximal firing rate of aged regular spiking interneurons. In the mossy fibers (MF) to interneurons synapse, a switch in the AMPA receptor subunit composition was found in aged interneurons. Young regular spiking interneurons predominantly express CP AMPA receptors and MF LTD. By contrast, aged regular spiking interneurons contain a higher proportion of CI AMPA receptors and respond with MF LTP. We show for the first time that the specialized MF terminals contacting interneurons, retain synaptic capabilities and provide a novel insight of the interneuron's function during aging. (C) 2021 Elsevier Inc. All rights reserved.

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