4.5 Review

Treatment of axial spondyloarthritis: an update

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Review Rheumatology

Fibromyalgia in Axial Spondyloarthritis A Meta-analysis

Seung Min Son et al.

Summary: This study compared the demographic characteristics, disease activity, functional status, and quality of life between patients with axial spondyloarthritis and fibromyalgia and patients with axial spondyloarthritis without fibromyalgia. The results showed that patients with fibromyalgia had higher pain severity, disease activity, and worse quality of life than patients without fibromyalgia.

JCR-JOURNAL OF CLINICAL RHEUMATOLOGY (2022)

Article Rheumatology

Safety and Efficacy of Upadacitinib in Patients With Active Ankylosing Spondylitis and an Inadequate Response to Nonsteroidal Antiinflammatory Drug Therapy: One-Year Results of a Double-Blind, Placebo-Controlled Study and Open-Label Extension

Atul Deodhar et al.

Summary: Upadacitinib 15 mg once daily demonstrated sustained and consistent efficacy in patients with ankylosing spondylitis over 1 year. Patients who switched from placebo to upadacitinib at week 14 showed similar efficacy compared to those who received continuous upadacitinib treatment.

ARTHRITIS & RHEUMATOLOGY (2022)

Review Rheumatology

Tumor Necrosis Factor Inhibitor Dose Reduction for Axial Spondyloarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Daeria O. Lawson et al.

Summary: Reducing the dose of tumor necrosis factor inhibitor therapy may not provide significant clinical benefits for patients with axial spondyloarthritis. Maintaining the standard dose may improve sustained disease activity and help prevent disease flare-ups.

ARTHRITIS CARE & RESEARCH (2021)

Article Rheumatology

Improvement of Signs and Symptoms of Nonradiographic Axial Spondyloarthritis in Patients Treated With Secukinumab: Primary Results of a Randomized, Placebo-Controlled Phase III Study

Atul Deodhar et al.

Summary: The study demonstrates that secukinumab 150 mg provides significant and sustained improvement in patients with active nonradiographic axial spondyloarthritis (SpA) through 52 weeks. The safety profile is consistent with previous reports.

ARTHRITIS & RHEUMATOLOGY (2021)

Review Dermatology

Use of IL-23 Inhibitors for the Treatment of Plaque Psoriasis and Psoriatic Arthritis: A Comprehensive Review

Kevin Yang et al.

Summary: Psoriasis is a common inflammatory skin disease with significant impact on quality of life. Biologic drugs like ustekinumab and guselkumab have shown efficacy in treating moderate-to-severe psoriasis and psoriatic arthritis with a favorable risk profile.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2021)

Article Rheumatology

Continuing versus withdrawing ixekizumab treatment in patients with axial spondyloarthritis who achieved remission: efficacy and safety results from a placebo-controlled, randomised withdrawal study (COAST-Y)

Robert B. M. Landewe et al.

Summary: The objective of the study was to evaluate the effect of continuing or withdrawing ixekizumab in patients with axial spondyloarthritis who had achieved remission. Results showed that patients who continued treatment with IXE were significantly less likely to experience a flare and had a delayed time-to-flare compared to those who withdrew to placebo.

ANNALS OF THE RHEUMATIC DISEASES (2021)

Article Rheumatology

Tofacitinib for the treatment of ankylosing spondylitis: a phase III, randomised, double-blind, placebo-controlled study

Atul Deodhar et al.

Summary: Tofacitinib demonstrated significantly greater efficacy compared to placebo in treating active ankylosing spondylitis in adults, with good safety profile and no new safety risks identified.

ANNALS OF THE RHEUMATIC DISEASES (2021)

Article Rheumatology

Efficacy of a tight-control and treat-to-target strategy in axial spondyloarthritis: results of the open-label, pragmatic, cluster-randomised TICOSPA trial

Anna Molto et al.

Summary: The study compared the benefits of a tight-control/treat-to-target strategy in axial spondyloarthritis with usual care, with the primary outcome showing that the percentage of patients achieving a >=30% improvement on the ASAS-Health Index was 47.3% in the TC/T2T group and 36.1% in the UC group. Safety profiles were similar between the two groups.

ANNALS OF THE RHEUMATIC DISEASES (2021)

Article Rheumatology

Maintenance of clinical remission in early axial spondyloarthritis following certolizumab pegol dose reduction

Robert B. M. Landewe et al.

ANNALS OF THE RHEUMATIC DISEASES (2020)

Review Rheumatology

The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies

Dennis G. McGonagle et al.

ANNALS OF THE RHEUMATIC DISEASES (2019)

Editorial Material Rheumatology

Why did IL-23p19 inhibition fail in AS: a tale of tissues, trials or translation?

Stefan Siebert et al.

ANNALS OF THE RHEUMATIC DISEASES (2019)

Review Chemistry, Medicinal

Lights and shadows of NSAIDs in bone healing: the role of prostaglandins in bone metabolism

Barbara Lisowska et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2018)

Article Rheumatology

The Effectiveness of Structured Group Education on Ankylosing Spondylitis Patients

Meliha Kasapoglu Aksoy et al.

JCR-JOURNAL OF CLINICAL RHEUMATOLOGY (2017)

Review Rheumatology

Switching tumor necrosis factor inhibitors in the treatment of axial spondyloarthritis

Atul Deodhar et al.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2017)

Article Rheumatology

Treat to Target in Axial Spondyloarthritis: What Are the Issues?

Abhijeet Danve et al.

CURRENT RHEUMATOLOGY REPORTS (2017)

Review Rheumatology

2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis

Desiree van der Heijde et al.

ANNALS OF THE RHEUMATIC DISEASES (2017)

Article Medicine, General & Internal

Patients With Ankylosing Spondylitis Have Increased Cardiovascular and Cerebrovascular Mortality A Population-Based Study

Nisha Nigil Haroon et al.

ANNALS OF INTERNAL MEDICINE (2015)

Article Medicine, General & Internal

Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis

Dominique Baeten et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Review Medicine, General & Internal

TNF-alpha inhibitors for ankylosing spondylitis

Lara J. Maxwell et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2015)

Review Medicine, General & Internal

Non-steroidal anti-inflammatory drugs (NSAIDs) for axial spondyloarthritis (ankylosing spondylitis and non-radiographic axial spondyloarthritis)

Feline P. B. Kroon et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2015)

Review Rheumatology

Exercise therapy for spondyloarthritis: a systematic review

Tom O'Dwyer et al.

RHEUMATOLOGY INTERNATIONAL (2014)

Review Rheumatology

The Interleukin-23/Interleukin-17 Axis in Spondyloarthritis Pathogenesis Th17 and Beyond

Judith A. Smith et al.

ARTHRITIS & RHEUMATOLOGY (2014)

Article Rheumatology

Predicting the outcome of ankylosing spondylitis therapy

Nathan Vastesaeger et al.

ANNALS OF THE RHEUMATIC DISEASES (2011)

Article Rheumatology

Exercise in Ankylosing Spondylitis: Discrepancies Between Recommendations and Reality

Laura A. Passalent et al.

JOURNAL OF RHEUMATOLOGY (2010)

Editorial Material Ophthalmology

Nonsteroidal Anti-inflammatory Drugs for Prophylaxis of Acute Anterior Uveitis

Ralph D. Levinson et al.

OCULAR IMMUNOLOGY AND INFLAMMATION (2010)

Article Rheumatology

Radiographic Findings Following Two Years of Infliximab Therapy in Patients With Ankylosing Spondylitis

Desiree van der Heijde et al.

ARTHRITIS AND RHEUMATISM (2008)

Letter Rheumatology

Treatment of active ankylosing spondylitis with pamidronate

H Haibel et al.

RHEUMATOLOGY (2003)