期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 23, 期 5, 页码 369-382出版社
NATURE PORTFOLIO
DOI: 10.1038/s41580-022-00460-3
关键词
-
类别
资金
- European Union's Horizon 2020 research and innovation programme under Marie Skodowska-Curie [860303]
- Fondation ARC [PGA1RF20190208474]
- BBSRC [BB/P006205/1]
- Fondation pour la Recherche Medicale Espoirs de la Recherche [FRM 2020-2023]
- CNRS
- Institut Curie
- European Research Council (ERC) [851936]
- Netherlands Organization for Scientific Research (NWO) [18367]
- BBSRC [BB/P006205/1] Funding Source: UKRI
- European Research Council (ERC) [851936] Funding Source: European Research Council (ERC)
Extracellular vesicles (EVs) play a significant role in cell-cell communication, but there are still many questions regarding their delivery in vivo. This article highlights the progress and challenges in understanding the importance of EV-mediated communication and provides recommendations for addressing these issues.
Extracellular vesicles (EVs) mediate cell-cell communication in physiology and pathology but many questions remain about the mechanisms governing their delivery to recipient cells. This Expert Recommendation article highlights areas of progress and challenges in establishing the importance of EV-mediated communication in vivo. Extracellular vesicles (EVs) are increasingly recognized as important mediators of intercellular communication. They have important roles in numerous physiological and pathological processes, and show considerable promise as novel biomarkers of disease, as therapeutic agents and as drug delivery vehicles. Intriguingly, however, understanding of the cellular and molecular mechanisms that govern the many observed functions of EVs remains far from comprehensive, at least partly due to technical challenges in working with these small messengers. Here, we highlight areas of consensus as well as contentious issues in our understanding of the intracellular and intercellular journey of EVs: from biogenesis, release and dynamics in the extracellular space, to interaction with and uptake by recipient cells. We define knowledge gaps, identify key questions and challenges, and make recommendations on how to address these.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据