Why novel mRNA modifications are so challenging and what we can do about it

The discovery of diverse chemical modifications of mRNA has spurred efforts to identify, map and characterize them. Yet aside from N-6-methyladenosine (m(6)A), progress in epitranscriptomics has been stymied by discrepant data. Here we discuss the main obstacles in studying novel mRNA modifications and offer insights into how to surmount them.

Automated summary

The paper discusses the challenges in studying novel mRNA modifications and provides insights on how to overcome them.