4.7 Article

Multiomics to elucidate inflammatory bowel disease risk factors and pathways

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Gastroenterology & Hepatology

Ultra-processed Foods and Risk of Crohn's Disease and Ulcerative Colitis: A Prospective Cohort Study

Chun-Han Lo et al.

Summary: The consumption of ultra-processed food is associated with an increased risk of Crohn's disease, but not with ulcerative colitis. Among different subgroups of ultra-processed food, ultra-processed breads and breakfast foods, frozen or shelf-stable ready-to-eat/heat meals, and sauces, cheeses, spreads, and gravies showed the strongest positive associations with the risk of Crohn's disease.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

Article Environmental Sciences

Plasma concentrations of perfluoroalkyl substances and risk of inflammatory bowel diseases in women: A nested case control analysis in the Nurses' Health Study cohorts

Paul Lochhead et al.

Summary: The study found inverse associations between certain PFAS concentrations and the risk of Crohn's disease, but no associations with ulcerative colitis risk. This suggests that elevated PFAS exposure may not be associated with higher risk of ulcerative colitis, and some PFAS concentrations may be inversely related to the development of Crohn's disease.

ENVIRONMENTAL RESEARCH (2022)

Article Gastroenterology & Hepatology

Residential Greenspace in Childhood Reduces Risk of Pediatric Inflammatory Bowel Disease: A Population-Based Cohort Study

Michael Elten et al.

Summary: The study found that higher exposure to residential greenspace during childhood was associated with a reduced risk of pediatric-onset IBD. This association was significant for both ulcerative colitis and Crohn's disease. There was no consistent association between maternal intrapartum greenspace exposure and pediatric-onset IBD.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2021)

Review Environmental Sciences

Prenatal air pollution exposure and neurodevelopment: A review and blueprint for a harmonized approach within ECHO

Heather E. Volk et al.

Summary: Studies show that prenatal air pollution exposure affects neurodevelopment, but current research has limitations in spatial and temporal exposure variation. The ECHO program offers opportunities to fill knowledge gaps and set standards for evaluating prenatal air pollution effects on neurodevelopment for improving children's health.

ENVIRONMENTAL RESEARCH (2021)

Article Gastroenterology & Hepatology

Transcription and DNA Methylation Patterns of Blood-Derived CD8+ T Cells Are Associated With Age and Inflammatory Bowel Disease But Do Not Predict Prognosis

Marco Gasparetto et al.

Summary: The study aimed to validate the correlation between CD8(+) T-cell gene expression and disease outcome in IBD patients, but failed to reproduce the previously reported findings. It highlights the challenges of developing prognostic biomarkers for IBD patients and stresses the importance of validation in large, independent cohorts before clinical application.

GASTROENTEROLOGY (2021)

Review Environmental Sciences

The use of dried blood spots for characterizing children's exposure to organic environmental chemicals

Dana Boyd Barr et al.

Summary: Biomonitoring is a commonly used tool for assessing exposure to organic environmental chemicals, with dried blood spots (DBS) considered as a potential matrix for blood collection in children. Studies have evaluated the measurement of organic environmental toxicants in both archived and prospectively collected DBS, but the level of validation varies among these studies.

ENVIRONMENTAL RESEARCH (2021)

Article Gastroenterology & Hepatology

Novel Fecal Biomarkers That Precede Clinical Diagnosis of Ulcerative Colitis

Heather J. Galipeau et al.

Summary: Increased fecal proteolytic activity was found before the clinical diagnosis of UC, which may serve as a noninvasive biomarker of inflammation associated with changes in gut microbiota. The study suggests potential therapeutic targets for at-risk populations based on antiprotease treatments.

GASTROENTEROLOGY (2021)

Article Gastroenterology & Hepatology

Effects of Intestinal Fungi and Viruses on Immune Responses and Inflammatory Bowel Diseases

Iliyan D. Iliev et al.

Summary: The intestinal microbiota is composed of a variety of fungal and viral components in addition to bacteria, which interact with the immune system and impact human physiology. Studies have shown that alterations in fungal and viral species in the gut are associated with inflammatory and autoimmune diseases, with potential to activate host-protective immune pathways while also contributing to inflammatory bowel disease. Modernization and the COVID-19 pandemic have introduced humans to new fungi and viruses, the consequences of which remain unknown. Lessons learned from animal studies on common gut viruses and fungi shed light on their impacts on health and intestinal diseases.

GASTROENTEROLOGY (2021)

Article Gastroenterology & Hepatology

Longitudinal Changes in Fecal Calprotectin Levels Among Pregnant Women With and Without Inflammatory Bowel Disease and Their Babies

Eun Soo Kim et al.

Summary: Pregnancy is associated with reduced inflammatory activity in mothers with IBD, however, babies born to mothers with IBD show subclinical inflammation in early life. The study findings suggest a correlation between maternal FC levels and bacterial abundance.

GASTROENTEROLOGY (2021)

Article Gastroenterology & Hepatology

Healthy Cotwins Share Gut Microbiome Signatures With Their Inflammatory Bowel Disease Twins and Unrelated Patients

Eelco C. Brand et al.

Summary: The gut microbiome of healthy cotwins from IBD-discordant twin pairs displays IBD-like signatures, potentially preceding the onset of IBD. However, longitudinal follow-up studies are needed to infer a causal relationship.

GASTROENTEROLOGY (2021)

Article Gastroenterology & Hepatology

Longitudinal Autonomic Nervous System Measures Correlate With Stress and Ulcerative Colitis Disease Activity and Predict Flare

Robert P. Hirten et al.

Summary: This study found significant associations between HRV and stress, inflammation, symptoms, and fecal calprotectin in UC patients. Changes in HRV indices were observed before the development of symptomatic or inflammatory flare.

INFLAMMATORY BOWEL DISEASES (2021)

Article Genetics & Heredity

Large-scale association analyses identify host factors influencing human gut microbiome composition

Alexander Kurilshikov et al.

Summary: The study revealed significant effects of host genetic variation on microbial composition, with the lactase (LCT) gene locus showing an age-dependent association with Bifidobacterium abundance. Other associations, while suggestive, were enriched for taxa with high heritability and for genes expressed in the intestine and brain.

NATURE GENETICS (2021)

Article Genetics & Heredity

Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease

Hari K. Somineni et al.

Summary: This study explored the genetic risk differences for inflammatory bowel disease among individuals with African American and European ancestries, revealing variations in gene effect sizes and allele frequencies. While there is a significant overlap in common variant risk for inflammatory bowel disease susceptibility between individuals of African and European ancestries, there are subtle differences in polygenic risk scores.

AMERICAN JOURNAL OF HUMAN GENETICS (2021)

Review Biochemistry & Molecular Biology

Hallmarks of environmental insults

Annette Peters et al.

Summary: Environmental insults such as contaminated air, water, and food expose human beings to a plethora of chemicals and stressors, impacting health at all stages of life. The proposed eight hallmarks of environmental insults encompass oxidative stress, genomic alterations, epigenetic changes, and disruptions to various bodily functions, offering insight into the severe health effects induced by complex mixtures of environmental exposures.
Article Environmental Sciences

Gestational and childhood exposure to per- and polyfluoroalkyl substances and cardiometabolic risk at age 12 years

Nan Li et al.

Summary: The study revealed that children with higher gestational exposure to PFOA and PFHxS were associated with unfavorable cardiometabolic risk in adolescence, primarily driven by insulin resistance and adiponectin to leptin ratio. Other individual cardiometabolic risk factors associated with gestational PFOA included insulin and waist circumference.

ENVIRONMENT INTERNATIONAL (2021)

Article Health Care Sciences & Services

Use of Physiological Data From a Wearable Device to Identify SARS-CoV-2 Infection and Symptoms and Predict COVID-19 Diagnosis: Observational Study

Robert P. Hirten et al.

Summary: This study found that HRV metrics collected through wearable devices can predict the diagnosis of COVID-19 and identify related symptoms. Significant changes in HRV were observed prior to the diagnosis of COVID-19, demonstrating the predictive ability of this metric to identify COVID-19 infection.

JOURNAL OF MEDICAL INTERNET RESEARCH (2021)

Article Environmental Sciences

Placental gene networks at the interface between maternal PM2.5 exposure early in gestation and reduced infant birthweight

Maya A. Deyssenroth et al.

Summary: This study identified a sensitive window during which maternal exposure to PM2.5 was significantly associated with reduced infant birthweight. Specific placental genes related to amino acid transport and cellular respiration may impact infant birthweight and maternal PM2.5 exposure levels. These findings suggest that maternal PM2.5 exposure may alter placental programming of fetal growth, leading to potential downstream health effects.

ENVIRONMENTAL RESEARCH (2021)

Article Gastroenterology & Hepatology

Sa509 RISK FACTORS ASSOCIATED WITH FAMILIAL INFLAMMATORY BOWEL DISEASE

Catarina F. Gomes et al.

GASTROENTEROLOGY (2021)

Article Gastroenterology & Hepatology

Results of the Seventh Scientific Workshop of ECCO: Precision Medicine in IBD-Prediction and Prevention of Inflammatory Bowel Disease

Joana Torres et al.

Summary: Inflammatory bowel disease is a complex chronic disorder with no known cure, causing substantial burden to patients. New strategies for preventing the global increase of IBD are urgently needed. Data on the preclinical period preceding disease diagnosis may hold the key to disease triggers and early intervention, potentially leading to improved understanding, prediction and prevention of the disease.

JOURNAL OF CROHNS & COLITIS (2021)

Article Gastroenterology & Hepatology

Deep Analysis of the Peripheral Immune System in IBD Reveals New Insight in Disease Subtyping and Response to Monotherapy or Combination Therapy

Roman Kosoy et al.

Summary: The study analyzed immune cell types in IBD patients and controls and found that certain types were commonly affected in IBD. The immune phenotype differed between ulcerative colitis and Crohn's disease, with further distinctions within disease subtypes. Treatment with thiopurine or anti-TNF medications led to changes in immune cell populations, with different patterns observed in monotherapy and combination therapy. The findings provide insights into potential mechanisms behind the effectiveness of combination therapy in IBD.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2021)

Article Gastroenterology & Hepatology

Anti-Microbial Antibody Response is Associated With Future Onset of Crohn's Disease Independent of Biomarkers of Altered Gut Barrier Function, Subclinical Inflammation, and Genetic Risk

Sun-Ho Lee et al.

Summary: High baseline total positive antibody response is associated with an increased risk of developing CD in the future, independently of abnormal gut barrier function, subclinical inflammation, and CD-related genetic risks. Causal mediation analysis showed that the effect of high AS on future CD development is partially mediated through preclinical gut inflammation.

GASTROENTEROLOGY (2021)

Article Gastroenterology & Hepatology

Systemic Inflammation in Preclinical Ulcerative Colitis

Daniel Bergemalm et al.

Summary: In preclinical ulcerative colitis, several inflammatory proteins are up-regulated years before diagnosis, which can effectively predict the risk of developing ulcerative colitis. These proteins are highly indicative of an ulcerative colitis diagnosis and show early upregulation upon exposure to genetic and environmental risk factors.

GASTROENTEROLOGY (2021)

Review Medicine, General & Internal

Early life exposures and the risk of inflammatory bowel disease: Systematic review and meta-analyses

Manasi Agrawal et al.

Summary: Early life exposures can impact the risk of immune-mediated diseases like inflammatory bowel disease, with factors such as prenatal exposure to antibiotics, tobacco smoke, and early otitis media potentially increasing the risk of IBD, while breastfeeding may have a protective effect. Other early life risk factors showed limited and heterogeneous associations with the disease.

ECLINICALMEDICINE (2021)

Review Gastroenterology & Hepatology

Differences in Gut Microbiota in Patients With vs Without Inflammatory Bowel Diseases: A Systematic Review

Rapat Pittayanon et al.

GASTROENTEROLOGY (2020)

Review Multidisciplinary Sciences

Pathway paradigms revealed from the genetics of inflammatory bowel disease

Daniel B. Graham et al.

NATURE (2020)

Review Pediatrics

Metabolomics and adductomics of newborn bloodspots to retrospectively assess the early-life exposome

Lauren M. Petrick et al.

CURRENT OPINION IN PEDIATRICS (2020)

Editorial Material Gastroenterology & Hepatology

Inflammatory Bowel Disease Clusters Within Affected Sibships in Ashkenazi Jewish Multiplex Families

Elizabeth A. Spencer et al.

GASTROENTEROLOGY (2020)

Editorial Material Gastroenterology & Hepatology

Association Between Early-life Exposures and Inflammatory Bowel Diseases, Based on Analyses of Deciduous Teeth

Nilendra Nair et al.

GASTROENTEROLOGY (2020)

Article Gastroenterology & Hepatology

Novel mass spectrometry-based comprehensive lipidomic analysis of plasma from patients with inflammatory bowel disease

Shuko Iwatani et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2020)

Article Biochemistry & Molecular Biology

Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer

Francesca Petralia et al.

Review Pharmacology & Pharmacy

The Exposome: Molecules to Populations

Megan M. Niedzwiecki et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 59 (2019)

Article Gastroenterology & Hepatology

Gut mucosal virome alterations in ulcerative colitis

Tao Zuo et al.

Review Gastroenterology & Hepatology

Environmental Risk Factors for Inflammatory Bowel Diseases: An Umbrella Review of Meta-analyses

Daniele Piovani et al.

GASTROENTEROLOGY (2019)

Article Gastroenterology & Hepatology

Lipidomics in Ulcerative Colitis Reveal Alteration in Mucosal Lipid Composition Associated With the Disease State

Joseph Diab et al.

INFLAMMATORY BOWEL DISEASES (2019)

Article Multidisciplinary Sciences

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

Jason Lloyd-Price et al.

NATURE (2019)

Article Gastroenterology & Hepatology

Analysis of Genetic Association of Intestinal Permeability in Healthy First-degree Relatives of Patients with Crohn's Disease

Williams Turpin et al.

INFLAMMATORY BOWEL DISEASES (2019)

Article Multidisciplinary Sciences

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Darina Czamara et al.

NATURE COMMUNICATIONS (2019)

Review Immunology

The Emerging Epigenetic Role of CD8+T Cells in Autoimmune Diseases: A Systematic Review

Qiancheng Deng et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Biochemistry & Molecular Biology

Newborn dried blood spot samples in Denmark: the hidden figures of secondary use and research participation

Francisca Nordfalk et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2019)

Review Gastroenterology & Hepatology

Environmental triggers in IBD: a review of progress and evidence

Ashwin N. Ananthakrishnan et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

Article Chemistry, Analytical

Quantitative determination of non-lactose milk oligosaccharides

Sean Austin et al.

ANALYTICA CHIMICA ACTA (2018)

Article Gastroenterology & Hepatology

Plasma N-Glycan Signatures Are Associated With Features of Inflammatory Bowel Diseases

Florent Clerc et al.

GASTROENTEROLOGY (2018)

Article Multidisciplinary Sciences

Metabolic control of T cell immune response through glycans in inflammatory bowel disease

Ana M. Dias et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Oncology

Lipidomics unveils the complexity of the lipidome in metabolic diseases

Todd A. Lydic et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2018)

Review Gastroenterology & Hepatology

Systematic Review and Meta-analysis: Fecal Microbiota Transplantation for Treatment of Active Ulcerative Colitis

Neeraj Narula et al.

INFLAMMATORY BOWEL DISEASES (2017)

Article Public, Environmental & Occupational Health

Prenatal exposure to fine particles and polycyclic aromatic hydrocarbons and birth outcomes: a two-pollutant approach

W. A. Jedrychowski et al.

INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH (2017)

Article Gastroenterology & Hepatology

P478 The current place of probiotics in treatment of pouchitis: systematic review

L. Lichtenstein et al.

Journal of Crohns & Colitis (2017)

Review Medicine, General & Internal

Crohn's disease

Joana Torres et al.

LANCET (2017)

Review Medicine, General & Internal

Ulcerative colitis

Ryan Ungaro et al.

LANCET (2017)

Article Gastroenterology & Hepatology

The IBD interactome: an integrated view of aetiology, pathogenesis and therapy

Heitor S. P. de Souza et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

Article Gastroenterology & Hepatology

DNA Methylation Profiling in Inflammatory Bowel Disease Provides New Insights into Disease Pathogenesis

Edel McDermott et al.

JOURNAL OF CROHNS & COLITIS (2016)

Article Public, Environmental & Occupational Health

High-resolution metabolomics of occupational exposure to trichloroethylene

Douglas I. Walker et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2016)

Article Gastroenterology & Hepatology

Perinatal vitamin D levels are not associated with later risk of developing pediatric-onset inflammatory bowel disease: a Danish case-cohort study

Steffen U. Thorsen et al.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2016)

Article Biochemical Research Methods

Integrative random forest for gene regulatory network inference

Francesca Petralia et al.

BIOINFORMATICS (2015)

Article Public, Environmental & Occupational Health

A cohort incidence study of workers exposed to perfluorooctanoic acid (PFOA)

Kyle Steenland et al.

OCCUPATIONAL AND ENVIRONMENTAL MEDICINE (2015)

Article Biochemistry & Molecular Biology

STRING v10: protein-protein interaction networks, integrated over the tree of life

Damian Szklarczyk et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Obstetrics & Gynecology

Neonatal line on fetus and infant teeth An indicator of live birth and mode of delivery

Nergis Canturk et al.

EARLY HUMAN DEVELOPMENT (2014)

Article Biochemistry & Molecular Biology

Dysregulation of T cell receptor N-glycosylation: a molecular mechanism involved in ulcerative colitis

Ana M. Dias et al.

HUMAN MOLECULAR GENETICS (2014)

Article Gastroenterology & Hepatology

Human Milk Oligosaccharides Protect Against Enteropathogenic Escherichia coli Attachment In Vitro and EPEC Colonization in Suckling Mice

Carolin F. Manthey et al.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2014)

Editorial Material Toxicology

The Nature of Nurture: Refining the Definition of the Exposome

Gary W. Miller et al.

TOXICOLOGICAL SCIENCES (2014)

Article Gastroenterology & Hepatology

Oral contraceptives, reproductive factors and risk of inflammatory bowel disease

Hamed Khalili et al.

Article Medicine, General & Internal

Physical activity and risk of inflammatory bowel disease: prospective study from the Nurses' Health Study cohorts

Hamed Khalili et al.

BMJ-BRITISH MEDICAL JOURNAL (2013)

Review Cell Biology

Metabolomics: the apogee of the omics trilogy

Gary J. Patti et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Review Cell Biology

Next generation sequencing in epigenetics: Insights and challenges

Emma Meaburn et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2012)

Review Immunology

The epigenetics of autoimmunity

Francesca Meda et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2011)

Review Pediatrics

Epigenetics and environmental chemicals

Andrea Baccarelli et al.

CURRENT OPINION IN PEDIATRICS (2009)

Article Oncology

Hemoglobin adducts of benzene oxide in neonatal and adult dried blood spots

William E. Funk et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2008)

Article Multidisciplinary Sciences

Variations in DNA elucidate molecular networks that cause disease

Yanqing Chen et al.

NATURE (2008)

Article Biochemical Research Methods

BlotGIycoABC™, an integrated glycoblotting technique for rapid and large scale clinical glycomics

Yoshiaki Miura et al.

MOLECULAR & CELLULAR PROTEOMICS (2008)

Review Immunology

Mammalian glycosylation in immunity

Jamey D. Marth et al.

NATURE REVIEWS IMMUNOLOGY (2008)

Article Multidisciplinary Sciences

Self-assembling protein microarrays

N Ramachandran et al.

SCIENCE (2004)

Article Oncology

Albumin adducts of naphthalene metabolites as biomarkers of exposure to polycyclic aromatic hydrocarbons

S Waidyanatha et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2004)

Article Environmental Sciences

Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population

FP Perera et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2003)

Article Gastroenterology & Hepatology

Lack of common NOD2 variants in Japanese patients with Crohn's disease

N Inoue et al.

GASTROENTEROLOGY (2002)