Exosomes as novel biomarkers in metabolic disease and obesity-related cancers

Exosomes include plasma-transported vesicles that are secreted by human tissues and reflect metabolic status. The profile of exosomes (particularly microRNA content) is altered in metabolic disease. In type 2 diabetes mellitus, exosomes circulating in plasma induce transcriptional changes related to tumour progression and pro-metastatic phenotypes in target cancer cells, potentially linking obesity to cancer progression and metastasis.

Automated summary

Exosomes are plasma-transported vesicles secreted by human tissues that reflect metabolic status. The profile of exosomes, particularly the microRNA content, is altered in metabolic diseases. In type 2 diabetes mellitus, circulating exosomes in plasma can induce transcriptional changes related to tumor progression and pro-metastatic phenotypes in target cancer cells, potentially linking obesity to cancer progression and metastasis.