期刊
NATURE REVIEWS ENDOCRINOLOGY
卷 18, 期 6, 页码 327-328出版社
NATURE PORTFOLIO
DOI: 10.1038/s41574-022-00666-7
关键词
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Exosomes are plasma-transported vesicles secreted by human tissues that reflect metabolic status. The profile of exosomes, particularly the microRNA content, is altered in metabolic diseases. In type 2 diabetes mellitus, circulating exosomes in plasma can induce transcriptional changes related to tumor progression and pro-metastatic phenotypes in target cancer cells, potentially linking obesity to cancer progression and metastasis.
Exosomes include plasma-transported vesicles that are secreted by human tissues and reflect metabolic status. The profile of exosomes (particularly microRNA content) is altered in metabolic disease. In type 2 diabetes mellitus, exosomes circulating in plasma induce transcriptional changes related to tumour progression and pro-metastatic phenotypes in target cancer cells, potentially linking obesity to cancer progression and metastasis.
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