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Network pharmacology: the next paradigm in drug discovery
Andrew L. Hopkins
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Target deconvolution strategies in drug discovery
Georg C. Terstappen et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage
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HUMAN MOLECULAR GENETICS (2007)
Tricyclic antidepressant pharmacology and therapeutic drug interactions updated
P. K. Gillman
BRITISH JOURNAL OF PHARMACOLOGY (2007)
The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease
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SCIENCE (2006)
Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond
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Rescue of ΔF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules
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AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2006)
Identification of molecular target of AMP-activated protein kinase activator by affinity purification and mass spectrometry
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ANALYTICAL CHEMISTRY (2005)
Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia
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NATURE REVIEWS DRUG DISCOVERY (2004)
Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based models
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ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2004)
Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The discovery of ezetimibe: A view from outside the receptor
JW Clader
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An integrative biology approach for analysis of drug action in models of human vascular inflammation
EJ Kunkel et al.
FASEB JOURNAL (2004)
Glivec (ST1571, Imatinib), a rationally developed, targeted anticancer drug
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NATURE REVIEWS DRUG DISCOVERY (2002)
The human estrogen receptor-α is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators
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P2Y12, a new platelet ADP receptor, target of clopidogrel
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Identification and biological activity of the active metabolite of clopidogrel
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