期刊
NATURE NEUROSCIENCE
卷 25, 期 6, 页码 795-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41593-022-01059-9
关键词
-
资金
- Singapore National Research Foundation (NRF)
- NUS Yong Loo Lin School of Medicine [NUHSRO/2020/124/TMR/LOA]
- Singapore National Medical Research Council (NMRC) [LCG OFLCG19May-0035]
- NMRC [STaR20nov-0003]
- Google Research Award
- National Institutes of Health (NIH) [R01MH123245, R01AG068563A, R01MH120080]
- McDonnell Center for Systems Neuroscience at Washington University
- Healthy Brains Healthy Lives initiative from the Canada First Research Excellence Fund
- Canada Institute for Advanced Research CIFAR Artificial Intelligence Chairs program
This paper presents a simple yet powerful approach to translate predictive models from large-scale datasets to small-scale studies, improving the prediction capability. The results demonstrate that meta-matching can greatly enhance predictions of new phenotypes in small independent datasets in various scenarios.
We propose a simple framework-meta-matching-to translate predictive models from large-scale datasets to new unseen non-brain-imaging phenotypes in small-scale studies. The key consideration is that a unique phenotype from a boutique study likely correlates with (but is not the same as) related phenotypes in some large-scale dataset. Meta-matching exploits these correlations to boost prediction in the boutique study. We apply meta-matching to predict non-brain-imaging phenotypes from resting-state functional connectivity. Using the UK Biobank (N = 36,848) and Human Connectome Project (HCP) (N = 1,019) datasets, we demonstrate that meta-matching can greatly boost the prediction of new phenotypes in small independent datasets in many scenarios. For example, translating a UK Biobank model to 100 HCP participants yields an eight-fold improvement in variance explained with an average absolute gain of 4.0% (minimum = -0.2%, maximum = 16.0%) across 35 phenotypes. With a growing number of large-scale datasets collecting increasingly diverse phenotypes, our results represent a lower bound on the potential of meta-matching. Individual-level prediction is critical for precision medicine, but many neuroimaging prediction studies are underpowered. Here the authors present a simple yet powerful approach that effectively translates predictive models from big to small data.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据