Simulating a whole cell

Summary: This study presents a whole-cell fully dynamical kinetic model (WCM) of JCVI-syn3A, a minimal cell, to investigate its behavior and provide insights into the principles of life for this microorganism. The model reveals the strategies employed by the cell to balance its metabolism, genetic processes, and growth, and analyzes the energy economy of various processes. Integration of experimental data in building the kinetic model allows for the prediction of mRNA half-lives, comparison with qPCR results, and observation of doubling behavior.