CoLoRd: compressing long reads

The cost of maintaining exabytes of data produced by sequencing experiments every year has become a major issue in today's genomic research. In spite of the increasing popularity of third-generation sequencing, the existing algorithms for compressing long reads exhibit a minor advantage over the general-purpose gzip. We present CoLoRd, an algorithm able to reduce the size of third-generation sequencing data by an order of magnitude without affecting the accuracy of downstream analyses. CoLoRd achieves high compression rates for long-read sequencing data without affecting downstream analyses.

Automated summary

The cost of maintaining a large amount of data generated by third-generation sequencing has become a significant concern in genomic research. Existing algorithms for compressing long reads have only a slight advantage over general-purpose gzip. In this study, we introduce CoLoRd, an algorithm that can significantly reduce the size of third-generation sequencing data without compromising the accuracy of downstream analyses.