Targeting the gut and tumor microbiota in cancer

Article Medicine, General & Internal

SER-109, an Oral Microbiome Therapy for Recurrent Clostridioides difficile Infection

Paul Feuerstadt et al.

Summary: SER-109 microbiome therapy is superior to placebo in reducing the risk of recurrent C. difficile infection, and has a similar safety profile as placebo.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Toxicology

The Future of Uncertainty Factors With In Vitro Studies Using Human Cells

Michael Dourson et al.

Summary: New approach methodologies, particularly in vitro toxicology methods using human cells, are challenging traditional regulatory risk assessments. The use of human cells on a chip may eliminate the interspecies uncertainty factor, but additional data is needed to reduce or eliminate the intraspecies uncertainty factor. Collaboration between traditional risk assessors and those working with modern technologies is important to move forward.

TOXICOLOGICAL SCIENCES (2022)

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Article Oncology

Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis

Satoru Yonekura et al.

Summary: Malignant processes can cause atrophy of the ileal mucosa, leading to dysbiosis of the microbiome. Blocking beta-adrenergic receptors and reducing gut microbiota can prevent cancer-induced ileopathy and slow tumor growth.

CANCER DISCOVERY (2022)

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Review Oncology

Hallmarks of Cancer: New Dimensions

Douglas Hanahan

Summary: The concept of the hallmarks of cancer is a tool for simplifying the complexity of cancer phenotypes and genotypes into basic principles. This article proposes phenotypic plasticity and disrupted differentiation as distinct hallmark capabilities, and discusses nonmutational epigenetic reprogramming and polymorphic microbiomes as enabling characteristics. Additionally, the importance of senescent cells in the tumor microenvironment is highlighted. The integrative concept of the hallmarks of cancer helps in understanding the mechanisms of cancer development and applying that knowledge to cancer medicine.

CANCER DISCOVERY (2022)

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Article Biochemistry & Molecular Biology

Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma

Karla A. Lee et al.

Summary: An analysis of metagenomic sequencing of stool samples reveals the association between gut microbiome and response to immune checkpoint blockade therapy in melanoma patients. However, there is limited consistency in the microbiome-based signatures across different populations. Future studies should consider larger sample sizes and examine the complex interplay between clinical factors and the gut microbiome.

NATURE MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Nivolumab plus ipilimumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial

Nazli Dizman et al.

Summary: Adding a live bacterial product to an immunotherapy combination can enhance the clinical outcome in patients with metastatic renal cell carcinoma, showing longer progression-free survival and higher response rate.

NATURE MEDICINE (2022)

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Article Oncology

Differential immune microenvironmental features of microsatellite-unstable colorectal cancers according toFusobacterium nucleatumstatus

Ji Ae Lee et al.

Summary: The study found that in MSI-high CRCs, tumors with high levels of Fn were correlated with larger size and more advanced invasion depth. Fn-high tumors showed lower density of FoxP3(+) cells throughout the tumor and an increased ratio of CD163(+)cells to CD68(+)cells in the CT area of MSI-high CRCs.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

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Article Oncology

The intratumoral microbiome: Characterization methods and functional impact

Clement J. F. Heymann et al.

Summary: Live-pathogenic bacteria have been identified inside tumors for centuries and offer opportunities for metabolic engineering in various clinical fields. However, due to the low microbial biomass nature of tumors, characterizing the tumor microbiome remains a challenge.

CANCER LETTERS (2021)

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Review Biochemistry & Molecular Biology

Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment

Khiem C. Lam et al.

Summary: This study reveals how the microbiota influences the immune components of the TME to improve cancer therapy. Modulating the microbiota can trigger the IFN-I-NK cell-DC axis within tumors, enhancing the efficacy of immune checkpoint blockade (ICB).

CELL (2021)

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Review Biochemistry & Molecular Biology

Hallmarks of response, resistance, and toxicity to immune checkpoint blockade

Golnaz Morad et al.

Summary: This passage discusses the unprecedented advances in cancer treatment with immune checkpoint blockade (ICB), highlighting the critical need for insights into factors intrinsic and extrinsic to the host that impact ICB response and toxicity. There has been substantial progress in understanding the impact of host-intrinsic factors and the exposome on host physiology and response to treatment, representing the hallmarks of response, resistance, and toxicity to ICB in current day.

CELL (2021)

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Review Oncology

Gut microbiota influence tumor development and Alter interactions with the human immune system

Yanshan Ge et al.

Summary: Recent scientific advances have shown the complex relationship between the gut microbiome and cancer. Changes in gut microbiota composition can lead to immune dysregulation, promoting chronic inflammation and tumor development. Gut microorganisms and their metabolites can affect inflammation and tumorigenesis in specific organs through various axes of interaction.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Multidisciplinary Sciences

Defining HPV-specific B cell responses in patients with head and neck cancer

Andreas Wieland et al.

Summary: Detailed analyses of B cells in the tumor microenvironment of HPV-linked head and neck cancers reveal strong humoral immune responses to HPV antigens and the secretion of HPV-specific antibodies in situ. The findings suggest that tumor-infiltrating B cells could potentially be utilized for the development of therapeutic agents in human cancer.

NATURE (2021)

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Article Multidisciplinary Sciences

Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

Erez N. Baruch et al.

Summary: This study conducted a phase 1 clinical trial and found that FMT treatment in patients with anti-PD-1-refractory metastatic melanoma, along with reinduction of anti-PD-1 immunotherapy, resulted in clinical responses in some patients. This suggests that modulating the gut microbiota could be a promising approach in cancer treatment.

SCIENCE (2021)

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Article Immunology

Microbiota-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer

Abigail E. Overacre-Delgoffe et al.

Summary: The study showed that introducing specific intestinal bacteria can enhance anti-colorectal cancer immunity and promote tumor control. This anti-tumor immunity is dependent on CD4(+) T cells, B cells, and NK cells.

IMMUNITY (2021)

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Article Cell Biology

Nod1 promotes colorectal carcinogenesis by regulating the immunosuppressive functions of tumor-infiltrating myeloid cells

Charles Maisonneuve et al.

Summary: The pioneering studies in the early 1980s indicated that bacterial peptidoglycan-derived muramyl peptides (MPs) have dual functions of either stimulation or immunosuppression depending on the chronicity of exposure. This study demonstrates the immunosuppressive potential of Nod1, the bacterial sensor of diaminopimelic acid (DAP)-containing MPs, in reprogramming macrophages and inducing myeloid-derived suppressor cells (MDSCs) to maintain their immunosuppressive activity, ultimately promoting tumor progression in colorectal cancer.

CELL REPORTS (2021)

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Article Medicine, Research & Experimental

Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade

Gladys Ferrere et al.

Summary: Limited experimental evidence suggests a link between nutrition and cancer immunosurveillance. This study demonstrates that ketogenic diet induces an anti-tumor effect through 3HB-mediated T cell-mediated cancer immunosurveillance. 3HB prevents immune checkpoint inhibition and promotes the expansion of specific T cells, while KD also leads to compositional changes in gut microbiota.

JCI INSIGHT (2021)

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Article Cell Biology

Oral administration of Akkermansia muciniphila elevates systemic antiaging and anticancer metabolites

Claudia Grajeda-Iglesias et al.

Aging-US (2021)

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Article Biochemistry & Molecular Biology

Neoadjuvant nivolumab or nivolumab plus ipilimumab in operable non-small cell lung cancer: the phase 2 randomized NEOSTAR trial

Tina Cascone et al.

Summary: The NEOSTAR trial showed that neoadjuvant treatment with nivolumab + ipilimumab combination therapy can improve pathologic response rates in operable NSCLC patients and has better clinical efficacy compared to nivolumab alone.

NATURE MEDICINE (2021)

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Article Biochemistry & Molecular Biology

The gut microbiome modulates the protective association between a Mediterranean diet and cardiometabolic disease risk

Dong D. Wang et al.

Summary: The study shows that a healthy Mediterranean-style diet is linked to specific functional and taxonomic components of the gut microbiome, and its protective effects on cardiometabolic health depend on microbial composition. In particular, the protective association between adherence to the Mediterranean diet and cardiometabolic disease risk is significantly stronger among participants with decreased abundance of Prevotella copri.

NATURE MEDICINE (2021)

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Article Multidisciplinary Sciences

Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis

Nicolo Pernigoni et al.

Summary: The gut microbiota enriched for species capable of converting androgen precursors into active androgens was found to contribute to the onset of castration resistance in CRPC. Ablation of the gut microbiota by antibiotic therapy delayed the emergence of castration resistance in mice. Fecal microbiota transplantation from CRPC patients rendered mice resistant to castration.

SCIENCE (2021)

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Article Multidisciplinary Sciences

Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

Christine N. Spencer et al.

Summary: The study suggests that dietary fiber intake is associated with significantly improved progression-free survival in melanoma patients receiving ICB treatment, especially without the use of probiotics. Preclinical studies demonstrate that a low-fiber diet or probiotics can impair the treatment response to anti-PD-1 therapy, leading to a lower frequency of interferon-gamma-positive cytotoxic T cells in the tumor microenvironment.

SCIENCE (2021)

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Article Multidisciplinary Sciences

Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients

Diwakar Davar et al.

Summary: The study demonstrated that fecal microbiota transplantation combined with anti-PD-1 therapy can overcome resistance to anti-PD-1 in a subset of PD-1 refractory melanoma patients, leading to clinical benefits. This approach induced changes in the gut microbiome and reprogrammed the tumor microenvironment, ultimately enhancing the efficacy of anti-PD-1 treatment.

SCIENCE (2021)

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Article Multidisciplinary Sciences

Comparison between 16S rRNA and shotgun sequencing data for the taxonomic characterization of the gut microbiota

Francesco Durazzi et al.

Summary: This study compared the taxonomic results obtained from 16S rRNA gene sequencing and whole shotgun metagenomic sequencing, finding that shotgun sequencing is more capable of identifying rare taxa in chicken gut microbiota profiling. Additionally, the less abundant genera detected only by shotgun sequencing were found to be biologically meaningful.

SCIENTIFIC REPORTS (2021)

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Article Multidisciplinary Sciences

Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of dietary composition

Laura C. D. Pomatto-Watson et al.

Summary: Cancer incidence increases with age and is a leading cause of death. Caloric restriction (CR) confers benefits on health and survival and delays cancer. Alternative dietary interventions for cancer protection, such as plant-based diet mimicking fasting (FMD), are being explored, with results showing that daily CR provides greater protection against tumor growth and metastasis compared to periodic caloric cycling in a murine model of breast cancer.

NATURE COMMUNICATIONS (2021)

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Review Biochemistry & Molecular Biology

Common and Novel Markers for Measuring Inflammation and Oxidative Stress Ex Vivo in Research and Clinical Practice-Which to Use Regarding Disease Outcomes?

Alain Menzel et al.

Summary: Many chronic diseases are associated with low-grade inflammation, which is closely related to oxidative stress that can either cause or be caused by inflammation. Valid biomarkers can help detect and track the progression of oxidative stress/inflammation and evaluate treatment efficacy, and should be stable, non-invasive, affordable and easy to determine. Commonly used markers include acute-phase proteins, cytokines, and oxidative stress products, but novel markers also show promise.

ANTIOXIDANTS (2021)

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Article Oncology

Impact of Use of Antibiotics on Response to Immune Checkpoint Inhibitors and Tumor Microenvironment

Uqba Khan et al.

Summary: The study found that using antibiotics during ICB significantly reduces the efficacy of immunotherapy, especially if antibiotics are used in the first 6 weeks after initiating ICB.

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS (2021)

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Article Biochemistry & Molecular Biology

Multifaceted modes of action of the anticancer probiotic Enterococcus hirae

Anne-Gaelle Goubet et al.

Summary: The study demonstrates that the gut microbiome's deviation is associated with resistance to cancer immunotherapy, and Enterococcus hirae can compensate for tumor-associated dysbiosis in various cancer models by stimulating T cell responses, activating autophagy, and altering the host microbiome.

CELL DEATH AND DIFFERENTIATION (2021)

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Article Cell Biology

Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity

Yao He et al.

Summary: Recent studies suggest that gut microbial metabolite butyrate can enhance the efficacy of oxaliplatin by modulation of CD8(+) T cell immunity through an ID2-dependent mechanism. This finding has important implications for cancer therapy in patients responding to oxaliplatin.

CELL METABOLISM (2021)

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Article Hematology

Haematological Malignancies in Older People 1 A comprehensive approach to therapy of haematological malignancies in older patients

Raul Cordoba et al.

Summary: Haematological malignancies are a diverse group of diseases with increasing incidence with age, particularly reaching a peak at 75-99 years, but overall survival is low for older adults, especially with acute leukaemias. Understanding the heterogeneity in outcomes, treatment challenges, and management of frailty and comorbidities among older patients can help physicians better address the burden and mortality of haematological cancers in aging populations.

LANCET HAEMATOLOGY (2021)

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Article Oncology

Gut microbiome is associated with the clinical response to anti-PD-1 based immunotherapy in hepatobiliary cancers

Jinzhu Mao et al.

Summary: This study investigated the relationship between gut microbiome and clinical response to anti-PD-1 immunotherapy in patients with advanced hepatobiliary cancers. Taxonomic signatures enriched in responders were effective biomarkers to predict the clinical response and survival benefit of immunotherapy. Functional annotation indicated that taxa associated with different metabolic pathways may modulate the clinical response to immunotherapy in hepatobiliary cancers.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Review Gastroenterology & Hepatology

Applying artificial intelligence in the microbiome for gastrointestinal diseases: A review

Tao Zeng et al.

Summary: In recent years, there has been a growing focus on the role of microbiome big data in gastrointestinal diseases, with the use of artificial intelligence technologies to extract relevant information.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Article Multidisciplinary Sciences

Identification of bacteria-derived HLA-bound peptides in melanoma

Shelly Kalaora et al.

Summary: The study found that peptides derived from intracellular bacteria can be presented by tumor cells, eliciting an immune response and shedding light on how bacteria influence immune activation and therapy responses.

NATURE (2021)

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Article Geosciences, Multidisciplinary

Effect of tectonic processes on biosphere-geosphere feedbacks across a convergent margin

Katherine M. Fullerton et al.

Summary: This study suggests that bacterial communities in the subsurface across the Costa Rican margin are influenced by deep tectonic processes and may play a role in reducing carbon transfer to the mantle. Through chemolithoautotrophic bacteria fixing CO2 derived from subducted slabs, the subsurface ecosystem could potentially sequester a significant amount of carbon, impacting the geosphere.

NATURE GEOSCIENCE (2021)

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Review Multidisciplinary Sciences

The microbiome and human cancer

Gregory D. Sepich-Poore et al.

Summary: Microbes play significant roles in cancer, and bacteria, viruses, and fungi are believed to be key actors in cancer immunotherapy. Although the number of microbes known to directly cause carcinogenesis is small, further research is needed to understand the causal relationship between microbes and cancer.

SCIENCE (2021)

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Article Oncology

Gut Microbiota and Antitumor Immunity: Potential Mechanisms for Clinical Effect

Erez N. Baruch et al.

Summary: The gut microbiota has been shown to influence the effectiveness of cancer immunotherapy by increasing intratumoral infiltration of CD8(+) effector T cells through multiple interlacing mechanisms. The therapeutic potential and limitations of different gut microbiota modulation techniques and their mechanisms of immune activation still need further exploration.

CANCER IMMUNOLOGY RESEARCH (2021)

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Article Microbiology

Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice

Hyo Shin Yoon et al.

Summary: The study demonstrates that Akkermansia muciniphila increases thermogenesis and GLP-1 secretion in mice by inducing uncoupling protein 1. A protein secreted by A. muciniphila, P9, interacts with ICAM-2 and can target metabolic diseases. This interaction could be a potential therapeutic target for such diseases.

NATURE MICROBIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

Miles C. Andrews et al.

Summary: The study showed that tumor-associated immune and genomic biomarkers of response to combined immune checkpoint blockade (CICB) in melanoma patients were similar to those of monotherapy, while toxicity from CICB was associated with a more diverse peripheral T-cell repertoire. Additionally, analysis of gut microbiota revealed a higher abundance of Bacteroides intestinalis in patients experiencing toxicity, along with an upregulation of the inflammatory factor IL-1 beta in colitis samples.

NATURE MEDICINE (2021)

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Article Multidisciplinary Sciences

Enterococcus peptidoglycan remodeling promotes checkpoint inhibitor cancer immunotherapy

Matthew E. Griffin et al.

Summary: This study found that members of the Enterococcus bacterial genus can improve checkpoint inhibitor immunotherapy in mouse tumor models through the expression and secretion of immune-active murpeptides. Additionally, expression of this enzyme in nonprotective bacteria can also enhance immunotherapy response, requiring another bacterial sensor for its activity.

SCIENCE (2021)

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Review Oncology

The Cancer Microbiome: Recent Highlights and Knowledge Gaps

Reece J. Knippel et al.

Summary: This review focuses on recent investigations to identify potential microbial species associated with cancer initiation and progression at specific body sites. Emerging experimental and translational data support the microbiome's contribution to cancer biology and disease progression, suggesting that disrupting microbiome features and pathways could lead to new approaches for improving cancer outcomes in patients.

CANCER DISCOVERY (2021)

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Review Oncology

Microbiota-Centered Interventions: The Next Breakthrough in Immuno-Oncology?

Lisa Derosa et al.

Summary: The dialogue between cancer and the immune system is greatly impacted by microenvironmental factors, especially the mucosal microbiota in the intestinal ecosystem. Antibiotics can reduce the effectiveness of immune checkpoint inhibitors, while fecal microbial transplantation may restore responsiveness in resistant melanoma patients. Understanding the role of gut bacteria in anticancer therapies is essential for future microbiota-centered interventions in immuno-oncology.

CANCER DISCOVERY (2021)

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Article Cell Biology

NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells

Yuetong Wang et al.

Summary: Research reveals that dysfunctional T cells in the tumor microenvironment are associated with decreased levels of NAMPT and NAD(+), and supplementation with NAD(+) can enhance the killing efficacy of T cells.

CELL REPORTS (2021)

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Article Oncology

Activating Mucosal-Associated Invariant T Cells Induces a Broad Antitumor Response

Benjamin Ruf et al.

Summary: MAIT cells exhibit potent antitumor function in vivo when activated by a combination of a synthetic riboflavin synthesis pathway-derived antigen and a TLR9 agonist. This activation leads to a strong systemic expansion and activation of MAIT cells, inducing a broad antitumor immune response in murine models. These findings suggest that MAIT cells are a promising target for cancer immunotherapy.

CANCER IMMUNOLOGY RESEARCH (2021)

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Article Immunology

Novel Immune Infiltrating Cell Signature Based on Cell Pair Algorithm Is a Prognostic Marker in Cancer

Hao Zhang et al.

Summary: In this study, the infiltration pattern of 65 immune cells was collected and evaluated to construct the Immune Cell Pair (ICP) score, which showed a robust reliability and efficacy in predicting the survival of patients with gliomas, in pan-cancer samples, and six independent cancer types. The ICP score was also correlated with the genomic alteration features in gliomas.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Safety and Efficacy of Fecal Microbiota Transplantation for Grade IV Steroid Refractory GI-GvHD Patients: Interim Results From FMT2017002 Trial

Ye Zhao et al.

Summary: FMT therapy for patients with grade IV steroid-refractory GI-GvHD demonstrates significant efficacy, prolonging survival and reducing mortality rates. During the follow-up period, both event-free survival and overall survival were improved in the FMT group. The therapy shows promising effectiveness with minimal side effects.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Cell Biology

The immunotoxicity, but not anti-tumor efficacy, of anti-CD40 and anti-CD137 immunotherapies is dependent on the gut microbiota

Stephen J. Blake et al.

Summary: Immune agonist antibodies (IAAs) show promise as immunotherapies targeting co-stimulatory receptors, but their clinical translation is hindered by immune-mediated toxicities. Research shows that the gut microbiota plays a role in the toxicity induced by IAAs, with germ-free or antibiotic-treated mice experiencing reduced toxicities compared to conventional mice. MyD88 signaling is crucial for the immune response induced by IAAs, with antibiotic treatment not impairing the efficacy of IAAs in anti-tumor activity.

CELL REPORTS MEDICINE (2021)

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Review Oncology

Biomarkers for immune checkpoint inhibition in non-small cell lung cancer (NSCLC)

J. Nicholas Bodor et al.

CANCER (2020)

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Article Oncology

Toll-like Receptor-6 Signaling Prevents Inflammation and Impacts Composition of the Microbiota During Inflammation-Induced Colorectal Cancer

Jee-Hyun Kim et al.

CANCER PREVENTION RESEARCH (2020)

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Article Oncology

Tumor Cell-Derived IL1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer

Shipra Das et al.

CANCER RESEARCH (2020)

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Article Immunology

Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer

Anthony R. Cillo et al.

IMMUNITY (2020)

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Article Oncology

Colibactin-positive Escherichia coli induce a procarcinogenic immune environment leading to immunotherapy resistance in colorectal cancer

Amelie Lopes et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

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Article Biochemistry & Molecular Biology

Fecal Microbiota Transplantation Prevents Intestinal Injury, Upregulation of Toll-Like Receptors, and 5-Fluorouracil/Oxaliplatin-Induced Toxicity in Colorectal Cancer

Ching-Wei Chang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Oncology

Microbial Diversity and Composition Is Associated with Patient-Reported Toxicity during Chemoradiation Therapy for Cervical Cancer

Aparna Mitra et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2020)

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Article Oncology

Impact of antibiotic exposure on the efficacy of immune checkpoint blockade in MSI-H metastatic CRC.

Victoria Serpas et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Article Immunology

Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling

Yaoyao Shi et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Article Multidisciplinary Sciences

B cells are associated with survival and immunotherapy response in sarcoma

Florent Petitprez et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Tertiary lymphoid structures improve immunotherapy and survival in melanoma

Rita Cabrita et al.

NATURE (2020)

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Article Multidisciplinary Sciences

B cells and tertiary lymphoid structures promote immunotherapy response

Beth A. Helmink et al.

NATURE (2020)

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Article Biotechnology & Applied Microbiology

Complete, closed bacterial genomes from microbiomes using nanopore sequencing

Eli L. Moss et al.

NATURE BIOTECHNOLOGY (2020)

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Article Oncology

Objective Response Rate Among Patients With Locally Advanced or Metastatic Sarcoma Treated With Talimogene Laherparepvec in Combination With Pembrolizumab A Phase 2 Clinical Trial

Ciara M. Kelly et al.

JAMA ONCOLOGY (2020)

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Article Biochemistry & Molecular Biology

Acetate promotes SNAI1 expression by ACSS2-mediated histone acetylation under glucose limitation in renal cell carcinoma cell

Lv Yao et al.

BIOSCIENCE REPORTS (2020)

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Article Oncology

Impact of antibiotic use during curative treatment of locally advanced head and neck cancers with chemotherapy and radiotherapy

Pablo Nenclares et al.

EUROPEAN JOURNAL OF CANCER (2020)

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Article Urology & Nephrology

Gut Bacteria Composition Drives Primary Resistance to Cancer Immunotherapy in Renal Cell Carcinoma Patients

Lisa Derosa et al.

EUROPEAN UROLOGY (2020)

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Article Multidisciplinary Sciences

The human tumor microbiome is composed of tumor type-specific intracellular bacteria

Deborah Nejman et al.

SCIENCE (2020)

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Article Microbiology

In Vivo Targeting of Clostridioides difficile Using Phage-Delivered CRISPR-Cas3 Antimicrobials

Kurt Selle et al.

MBIO (2020)

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Article Microbiology

Gut microbiota-derived indole 3-propionic acid protects against radiation toxicity via retaining acyl-CoA-binding protein

Hui-wen Xiao et al.

MICROBIOME (2020)

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Article Multidisciplinary Sciences

Microbiome analyses of blood and tissues suggest cancer diagnostic approach

Gregory D. Poore et al.

NATURE (2020)

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Article Biochemistry & Molecular Biology

Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer

Maria Paula Roberti et al.

NATURE MEDICINE (2020)

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Review Microbiology

Beyond Just Bacteria: Functional Biomes in the Gut Ecosystem Including Virome, Mycobiome, Archaeome and Helminths

Ravichandra Vemuri et al.

MICROORGANISMS (2020)

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Review Microbiology

Bacteriophage-mediated manipulation of the gut microbiome - promises and presents limitations

Torben Solbeck Rasmussen et al.

FEMS MICROBIOLOGY REVIEWS (2020)

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Review Biochemistry & Molecular Biology

Microbiota-Derived Metabolites in Tumor Progression and Metastasis

Tania Rossi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Medicine, Research & Experimental

Commensal bacteria stimulate antitumor responses via T cell cross-reactivity

Catherine A. Bessell et al.

JCI INSIGHT (2020)

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Review Oncology

The Role of the Microbiome in Cancer and Therapy Efficacy: Focus on Lung Cancer

Adrienne Halley et al.

ANTICANCER RESEARCH (2020)

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Article Biotechnology & Applied Microbiology

Directed remodeling of the mouse gut microbiome inhibits the development of atherosclerosis

Poshen B. Chen et al.

NATURE BIOTECHNOLOGY (2020)

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Article Gastroenterology & Hepatology

Gut microbiome, big data and machine learning to promote precision medicine for cancer

Giovanni Cammarota et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

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Article Multidisciplinary Sciences

Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy

Lukas F. Mager et al.

SCIENCE (2020)

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Article Urology & Nephrology

Stool Microbiome Profiling of Patients with Metastatic Renal Cell Carcinoma Receiving Anti-PD-1 Immune Checkpoint Inhibitors

Nicholas J. Salgia et al.

EUROPEAN UROLOGY (2020)

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Article Gastroenterology & Hepatology

Screening and eradication of Helicobacter pylori for gastric cancer prevention: the Taipei global consensus

Jyh-Ming Liou et al.

GUT (2020)

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Article Multidisciplinary Sciences

Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer

Aitziber Buque et al.

NATURE COMMUNICATIONS (2020)

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Article Medicine, General & Internal

HPV Vaccination and the Risk of Invasive Cervical Cancer

Jiayao Lei et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Oncology

The Gut Microbiome Is Associated with Clinical Response to Anti-PD-1/PD-L1 Immunotherapy in Gastrointestinal Cancer

Zhi Peng et al.

CANCER IMMUNOLOGY RESEARCH (2020)

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Article Oncology

The Gut Microbiome Associates with Immune Checkpoint Inhibition Outcomes in Patients with Advanced Non-Small Cell Lung Cancer

Taiki Hakozaki et al.

CANCER IMMUNOLOGY RESEARCH (2020)

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BMC MEDICAL GENOMICS (2019)

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NEW ENGLAND JOURNAL OF MEDICINE (2019)

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The Diversity of Gut Microbiome is Associated With Favorable Responses to Anti-Programmed Death 1 Immunotherapy in Chinese Patients With NSCLC

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Regulatory T Cells and Plasmacytoid Dendritic Cells Within the Tumor Microenvironment in Gastric Cancer Are Correlated With Gastric Microbiota Dysbiosis: A Preliminary Study

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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NATURE GENETICS (2018)

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NEW ENGLAND JOURNAL OF MEDICINE (2018)

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The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression

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CANCER DISCOVERY (2018)

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Fusobacterium nucleatum promotes M2 polarization of macrophages in the microenvironment of colorectal tumours via a TLR4-dependent mechanism

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CELL (2018)

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MICROBIOME (2018)

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FRONTIERS IN NUTRITION (2018)

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Helicobacter pylori Infection Modulates the Expression of miRNAs Associated With DNA Mismatch Repair Pathway

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Lithocholic Acid Stimulates IL-8 Expression in Human Colorectal Cancer Cells Via Activation of Erk1/2 MAPK and Suppression of STAT3 Activity

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Impact of antibiotics on outcome in patients with metastatic renal cell carcinoma treated with immune checkpoint inhibitors.

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BMJ-BRITISH MEDICAL JOURNAL (2017)

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BMJ-BRITISH MEDICAL JOURNAL (2017)

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ADXS11-001 Lm-LLO Immunotherapy, Mitomycin, 5-fluorouracil (5-FU) and Intensity modulated radiation therapy (IMRT) for Anal Cancer.

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Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy

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CELL (2017)

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Microbiota Disruption Induced by Early Use of Broad-Spectrum Antibiotics Is an Independent Risk Factor of Outcome after Allogeneic Stem Cell Transplantation

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BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2017)

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Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

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HPV E7 antigen-expressing Listeria-based immunotherapy (ADXS11-001) prior to robotic surgery for HPV-positive oropharyngeal cancer enhances HPV-specific T cell immunity

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CANCER RESEARCH (2016)

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JOURNAL OF CHROMATOGRAPHY A (2016)

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JOURNAL OF IMMUNOLOGY (2016)

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NATURE (2016)

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NEW ENGLAND JOURNAL OF MEDICINE (2016)

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NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade

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CANCER DISCOVERY (2016)

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Inherent bacterial DNA contamination of extraction and sequencing reagents may affect interpretation of microbiota in low bacterial biomass samples

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ONCOTARGET (2016)

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CELL REPORTS (2016)

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Revised Estimates for the Number of Human and Bacteria Cells in the Body

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PLOS BIOLOGY (2016)

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Efficacy of antineoplastic treatment is associated with the use of antibiotics that modulate intestinal microbiota

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ONCOIMMUNOLOGY (2016)

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CANCER BIOLOGY & MEDICINE (2016)

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Intestinal Blautia Is Associated with Reduced Death from Graft-versus-Host Disease

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BONE MARROW TRANSPLANTATION (2015)

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Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma

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Nivolumab in Previously Untreated Melanoma without BRAF Mutation

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NEW ENGLAND JOURNAL OF MEDICINE (2015)

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JAMA ONCOLOGY (2015)

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PLOS ONE (2015)

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Metagenomic Analysis of the Stool Microbiome in Patients Receiving Allogeneic Stem Cell Transplantation: Loss of Diversity Is Associated with Use of Systemic Antibiotics and More Pronounced in Gastrointestinal Graft-versus-Host Disease

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Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

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Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin

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Helicobacter pylori Causes Epigenetic Dysregulation of FOXD3 to Promote Gastric Carcinogenesis

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GASTROENTEROLOGY (2013)

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Vaccination Directed against the Human Endogenous Retrovirus-K Envelope Protein Inhibits Tumor Growth in a Murine Model System

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Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment

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An Escherichia coli Effector Protein Promotes Host Mutation via Depletion of DNA Mismatch Repair Proteins

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Vaginal Microbiome: Rethinking Health and Disease

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Gut microbiota-derived propionate reduces cancer cell proliferation in the liver

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Bacterial Inactivation of the Anticancer Drug Doxorubicin

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Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity

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IMMUNITY (2012)

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Fecal microbial determinants of fecal and systemic estrogens and estrogen metabolites: a cross-sectional study

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In vitro bioaccessibility and gut biotransformation of polyphenols present in the water-insoluble cocoa fraction

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Peripheral education of the immune system by colonic commensal microbiota

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Cytolethal distending toxin: a conserved bacterial genotoxin that blocks cell cycle progression, leading to apoptosis of a broad range of mammalian cell lineages

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ARCHIVES OF MICROBIOLOGY (2010)

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Lithocholic acid upregulates uPAR and cell invasiveness via MAPK and AP-1 signaling in colon cancer cells

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Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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The Innate Immune Receptor Nod1 Protects the Intestine from Inflammation-induced Tumorigenesis

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Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

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Deoxycholic acid promotes the growth of colonic aberrant crypt foci

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Adaptation of solitary intestinal lymphoid tissue in response to microbiota and chemokine receptor CCR7 signaling

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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The origin of atmospheric oxygen on Earth: The innovation of oxygenic photosynthesis

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