STINGing type I IFN-mediated immunopathology in COVID-19

The molecular basis for type I interferon (IFN)-mediated immunopathology is unclear. New data now identify the cGAS-STING pathway as a major driver of pathological type I IFN responses in COVID-19.

Automated summary

This study identifies the cGAS-STING pathway as a major driver of pathological type I interferon responses in COVID-19.