4.8 Article

Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Vassily Trubetskoy et al.

Summary: In this study, a two-stage genome-wide association study was conducted to identify common variants associated with schizophrenia. The results revealed 287 distinct genomic loci and 120 genes likely to be involved in the development of schizophrenia. This research provides valuable insights into the pathophysiology of schizophrenia and offers a resource for further mechanistic studies.

NATURE (2022)

Article Multidisciplinary Sciences

Population-specific causal disease effect sizes in functionally important regions impacted by selection

Huwenbo Shi et al.

Summary: The study identifies that trans-ethnic genetic correlation is significantly less than 1 for many diseases, limiting trans-ethnic polygenic risk prediction. Causal effect sizes are found to be more population-specific in functionally important regions, with skin and immune genes showing the highest population-specificity.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

A major role for common genetic variation in anxiety disorders

Kirstin L. Purves et al.

MOLECULAR PSYCHIATRY (2020)

Article Psychiatry

The Heterogeneity of Mental Health Assessment

Jennifer J. Newson et al.

FRONTIERS IN PSYCHIATRY (2020)

Article Multidisciplinary Sciences

The mutational constraint spectrum quantified from variation in 141,456 humans

Konrad J. Karczewski et al.

NATURE (2020)

Article Genetics & Heredity

Identification of common genetic risk variants for autism spectrum disorder

Jakob Grove et al.

NATURE GENETICS (2019)

Article Genetics & Heredity

Genome-wide association study identifies 30 loci associated with bipolar disorder

Eli A. Stahl et al.

NATURE GENETICS (2019)

Article Genetics & Heredity

A global overview of pleiotropy and genetic architecture in complex traits

Kyoko Watanabe et al.

NATURE GENETICS (2019)

Article Genetics & Heredity

A resource-efficient tool for mixed model association analysis of large-scale data

Longda Jiang et al.

NATURE GENETICS (2019)

Article Genetics & Heredity

Multivariate genome-wide analyses of the well-being spectrum

Bart M. L. Baselmans et al.

NATURE GENETICS (2019)

Article Biochemistry & Molecular Biology

Largest GWAS of PTSD (N=20070) yields genetic overlap with schizophrenia and sex differences in heritability

L. E. Duncan et al.

MOLECULAR PSYCHIATRY (2018)

Article Biochemistry & Molecular Biology

Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis

Paul D. Arnold et al.

MOLECULAR PSYCHIATRY (2018)

Article Genetics & Heredity

Multi-trait analysis of genome-wide association summary statistics using MTAG

Patrick Turley et al.

NATURE GENETICS (2018)

Article Biochemistry & Molecular Biology

Stimulation of entorhinal cortex-dentate gyrus circuitry is antidepressive

Sanghee Yun et al.

NATURE MEDICINE (2018)

Article Multidisciplinary Sciences

Analysis of shared heritability in common disorders of the brain

Verneri Anttila et al.

SCIENCE (2018)

Article Psychiatry

A polygenic p factor for major psychiatric disorders

Saskia Selzam et al.

TRANSLATIONAL PSYCHIATRY (2018)

Article Biochemical Research Methods

Massively parallel single-nucleus RNA-seq with DroNc-seq

Naomi Habib et al.

NATURE METHODS (2017)

Article Mathematics, Interdisciplinary Applications

Generalized Network Psychometrics: Combining Network and Latent Variable Models

Sacha Epskamp et al.

PSYCHOMETRIKA (2017)

Article Psychiatry

A network theory of mental disorders

Denny Borsboom

WORLD PSYCHIATRY (2017)

Review Psychiatry

GABAergic Mechanisms in Schizophrenia: Linking Postmortem and In Vivo Studies

Jeroen C. de Jonge et al.

FRONTIERS IN PSYCHIATRY (2017)

Article Biochemistry & Molecular Biology

Common psychiatric disorders share the same genetic origin: a multivariate sibling study of the Swedish population

E. Pettersson et al.

MOLECULAR PSYCHIATRY (2016)

Article Biochemistry & Molecular Biology

Meta-analysis of genome-wide association studies of anxiety disorders

T. Otowa et al.

MOLECULAR PSYCHIATRY (2016)

Article Psychology, Clinical

Cortical GABA markers identify a molecular subtype of psychotic and bipolar disorders

D. W. Volk et al.

PSYCHOLOGICAL MEDICINE (2016)

Article Multidisciplinary Sciences

Integrative analysis of 111 reference human epigenomes

Anshul Kundaje et al.

NATURE (2015)

Article Genetics & Heredity

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

Brendan K. Bulik-Sullivan et al.

NATURE GENETICS (2015)

Article Multidisciplinary Sciences

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

Kristin G. Ardlie et al.

SCIENCE (2015)

Article Multidisciplinary Sciences

Biological interpretation of genome-wide association studies using predicted gene functions

Tune H. Pers et al.

NATURE COMMUNICATIONS (2015)

Article Behavioral Sciences

Links between circadian rhythms and psychiatric disease

Ilia N. Karatsoreos

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2014)

Article Psychology, Clinical

The p Factor: One General Psychopathology Factor in the Structure of Psychiatric Disorders?

Avshalom Caspi et al.

CLINICAL PSYCHOLOGICAL SCIENCE (2014)

Editorial Material Genetics & Heredity

Linking the SWI/SNF complex to prostate cancer

Ryan S. Lee et al.

NATURE GENETICS (2013)

Article Psychiatry

Parent psychopathology and offspring mental disorders: results from the WHO World Mental Health Surveys

Katie A. McLaughlin et al.

BRITISH JOURNAL OF PSYCHIATRY (2012)

Article Psychology, Clinical

Is There a General Factor of Prevalent Psychopathology During Adulthood?

Benjamin B. Lahey et al.

JOURNAL OF ABNORMAL PSYCHOLOGY (2012)

Article Genetics & Heredity

GCTA: A Tool for Genome-wide Complex Trait Analysis

Jian Yang et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2011)

Article Psychiatry

Hippocampal Interneurons in Bipolar Disorder

Christine Konradi et al.

ARCHIVES OF GENERAL PSYCHIATRY (2011)

Article Neurosciences

Antidepressants increase neural progenitor cells in the human hippocampus

Maura Boldrini et al.

NEUROPSYCHOPHARMACOLOGY (2009)

Article Genetics & Heredity

PLINK: A tool set for whole-genome association and population-based linkage analyses

Shaun Purcell et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2007)

Article Cell Biology

Hippocampal CA1 pyramidal cell size is reduced in bipolar disorder

Lusha Liu et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2007)