DNMT3A binds ubiquitinated histones to regulate bivalent genes

A new study demonstrates that the disordered N-terminal domain of DNMT3A1 binds PRC1-catalyzed H2AK119ub, targeting DNA methylation to bivalent promoters in mouse brain cortical cells. Methylation around bivalent genes is critical for mouse postnatal development, and could be equally important in other cell types and in disease.

Automated summary

A new study reveals that the disordered N-terminal domain of DNMT3A1 binds to PRC1-catalyzed H2AK119ub, leading to targeted DNA methylation at bivalent promoters in mouse brain cortical cells. Methylation around bivalent genes plays a crucial role in postnatal development of mice and may have equal significance in other cell types and diseases.