Discovering missing heritability in whole-genome sequencing data

The gap between heritability estimates from twin studies and those from genotyping array data has puzzled researchers for over a decade. New research suggests that much of the 'missing' heritability is due to rare variants that can only be captured by whole-genome sequencing (WGS) data.

Automated summary

The gap between heritability estimates from twin studies and genotyping array data is largely due to rare variants, which can only be detected through whole-genome sequencing (WGS) data.