4.8 Article

Opening of glutamate receptor channel to subconductance levels

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Structure and desensitization of AMPA receptor complexes with type II TARP γ5 and GSG1L

Oleg Klykov et al.

Summary: AMPARs mediate the majority of excitatory neurotransmission and their function is regulated by auxiliary subunits. Different types of TARP auxiliary subunits have different roles, and the structural and mechanistic variations of complexes with auxiliary subunits endow AMPARs with broad functional capabilities.

MOLECULAR CELL (2021)

Review Pharmacology & Pharmacy

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

Kasper B. Hansen et al.

Summary: This study summarizes the physiological effects of L-glutamate and the importance of ionotropic glutamate receptors in brain function. Research on iGluRs has advanced rapidly, particularly in areas such as receptor structure, function, pharmacology, and roles in neurophysiology.

PHARMACOLOGICAL REVIEWS (2021)

Article Multidisciplinary Sciences

Nonselective cation permeation in an AMPA-type glutamate receptor

Johann Biedermann et al.

Summary: Fast excitatory synaptic transmission in the central nervous system relies on the AMPA-type glutamate receptor (AMPAR), which incorporates a nonselective cation channel. Recent studies combining molecular dynamic simulations and electrophysiology have revealed the ion permeation mechanisms of AMPA receptors, showing that Na+, K+, and Cs+ can permeate at physiological rates through a simple selectivity filter structure. The permissive architecture of the filter allows for rapid, nonselective cation permeation and copermeation by water, with Cs+ slightly more permeant than Na+ due to preferential binding sites.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Multidisciplinary Sciences

Gating and modulation of a hetero-octameric AMPA glutamate receptor

Danyang Zhang et al.

Summary: This study reveals the structure and active states of AMPAR complexes, demonstrating that TARP-gamma 8 and CNIH2 affect the gating regulation of AMPARs by binding to specific regions of the receptor, thereby promoting the transition to the active-state conformation.

NATURE (2021)

Article Multidisciplinary Sciences

A constricted opening in Kir channels does not impede potassium conduction

Katrina A. Black et al.

NATURE COMMUNICATIONS (2020)

Article Computer Science, Theory & Methods

GPU accelerated t-distributed stochastic neighbor embedding

David M. Chan et al.

JOURNAL OF PARALLEL AND DISTRIBUTED COMPUTING (2019)

Article Multidisciplinary Sciences

Bases of Bacterial Sodium Channel Selectivity Among Organic Cations

Yibo Wang et al.

SCIENTIFIC REPORTS (2019)

Article Physiology

Noncompetitive antagonists induce cooperative AMPA receptor channel gating

Edward Y. Shi et al.

JOURNAL OF GENERAL PHYSIOLOGY (2019)

Article Chemistry, Medicinal

Modulation of AMPA Receptor Gating by the Anticonvulsant Drug, Perampanel

Christine L. Yuan et al.

ACS MEDICINAL CHEMISTRY LETTERS (2019)

Article Chemistry, Multidisciplinary

Direct knock-on of desolvated ions governs strict ion selectivity in K+ channels

Wojciech Kopec et al.

NATURE CHEMISTRY (2018)

Article Neurosciences

Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors

Edward C. Twomey et al.

NEURON (2018)

Article Biochemistry & Molecular Biology

Structural Mechanisms of Gating in Ionotropic Glutamate Receptors

Edward C. Twomey et al.

BIOCHEMISTRY (2018)

Article Chemistry, Physical

Validity of the Electrodiffusion Model for Calculating Conductance of Simple Ion Channels

Andrew Pohorille et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2017)

Article Multidisciplinary Sciences

Channel opening and gating mechanism in AMPA-subtype glutamate receptors

Edward C. Twomey et al.

NATURE (2017)

Letter Biochemical Research Methods

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

Shawn Q. Zheng et al.

NATURE METHODS (2017)

Article Biochemical Research Methods

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

Ali Punjani et al.

NATURE METHODS (2017)

Article Multidisciplinary Sciences

Role of the Ion Channel Extracellular Collar in AMPA Receptor Gating

Maria V. Yelshanskaya et al.

SCIENTIFIC REPORTS (2017)

Article Biophysics

Unitary Properties of AMPA Receptors with Reduced Desensitization

Wei Zhang et al.

BIOPHYSICAL JOURNAL (2017)

Article Biochemistry & Molecular Biology

Activation and Desensitization Mechanism of AMPA Receptor-TARP Complex by Cryo-EM

Shanshuang Chen et al.

Article Biochemistry & Molecular Biology

Gctf: Real-time CTF determination and correction

Kai Zhang

JOURNAL OF STRUCTURAL BIOLOGY (2016)

Article Multidisciplinary Sciences

Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy

Edward C. Twomey et al.

SCIENCE (2016)

Article Cell Biology

Stargazin Modulation of AMPA Receptors

Sana A. Shaikh et al.

CELL REPORTS (2016)

Review Biochemistry & Molecular Biology

Hydrophobic Gating in Ion Channels

Prafulla Aryal et al.

JOURNAL OF MOLECULAR BIOLOGY (2015)

Review Neurosciences

Modulation of non-NMDA receptor gating by auxiliary subunits

James R. Howe

JOURNAL OF PHYSIOLOGY-LONDON (2015)

Article Neurosciences

Auxiliary proteins promote modal gating of AMPA- and kainate-type glutamate receptors

Wei Zhang et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2014)

Article Chemistry, Physical

Lipid14: The Amber Lipid Force Field

Callum J. Dickson et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2014)

Article Chemistry, Multidisciplinary

CHARMM-GUI Membrane Builder Toward Realistic Biological Membrane Simulations

Emilia L. Wu et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2014)

Article Physiology

Stargazin promotes closure of the AMPA receptor ligand-binding domain

David M. MacLean et al.

JOURNAL OF GENERAL PHYSIOLOGY (2014)

Article Biochemical Research Methods

Screening and large-scale expression of membrane proteins in mammalian cells for structural studies

April Goehring et al.

NATURE PROTOCOLS (2014)

Article Multidisciplinary Sciences

Structure of an agonist-bound ionotropic glutamate receptor

Maria V. Yelshanskaya et al.

SCIENCE (2014)

Article Multidisciplinary Sciences

Ion permeation in K+ channels occurs by direct Coulomb knock-on

David A. Koepfer et al.

SCIENCE (2014)

Article Multidisciplinary Sciences

Ultrastable gold substrates for electron cryomicroscopy

Christopher J. Russo et al.

SCIENCE (2014)

Article Chemistry, Physical

PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data

Daniel R. Roe et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2013)

Article Biochemical Research Methods

Towards automated crystallographic structure refinement with phenix.refine

Pavel V. Afonine et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2012)

Article Neurosciences

Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating

Anders S. Kristensen et al.

NATURE NEUROSCIENCE (2011)

Article Multidisciplinary Sciences

Atomistic mechanism for the activation and desensitization of an AMPA-subtype glutamate receptor

Hao Dong et al.

NATURE COMMUNICATIONS (2011)

Article Biophysics

Characterizing Single-Channel Behavior of GluA3 Receptors

Kinning Poon et al.

BIOPHYSICAL JOURNAL (2010)

Article Neurosciences

Gating Modes in AMPA Receptors

Martin Loynaz Prieto et al.

JOURNAL OF NEUROSCIENCE (2010)

Article Multidisciplinary Sciences

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

Alexander I. Sobolevsky et al.

NATURE (2009)

Article Chemistry, Multidisciplinary

Software news and updates - CHARNIM-GUI: A web-based grraphical user interface for CHARMM

Sunhwan Jo et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Comparison of multiple amber force fields and development of improved protein backbone parameters

Viktor Hornak et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2006)

Article Multidisciplinary Sciences

Effects of cyclothiazide on GluR1/AMPA receptors

S Fucile et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

On the binding determinants of the glutamate agonist with the glutamate receptor ligand binding domain

K Speranskiy et al.

BIOCHEMISTRY (2005)

Article Multidisciplinary Sciences

Stargazin modulates AMPA receptor gating and trafficking by distinct domains

S Tomita et al.

NATURE (2005)

Article Chemistry, Multidisciplinary

Development and testing of a general amber force field

JM Wang et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)

Article Biochemical Research Methods

Coot:: model-building tools for molecular graphics

P Emsley et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)

Article Chemistry, Multidisciplinary

UCSF chimera - A visualization system for exploratory research and analysis

EF Pettersen et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)

Article Neurosciences

Concentration-dependent substrate behavior of native AMPA receptors

TC Smith et al.

NATURE NEUROSCIENCE (2000)