4.8 Article

Neoantigen quality predicts immunoediting in survivors of pancreatic cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer

William Freed-Pastor et al.

Summary: The CD155/TIGIT axis can be utilized for immune evasion in chronic viral infections and cancers like pancreatic adenocarcinoma. Studies have shown that a significant portion of PDAC patients have predicted high-affinity MHC class I-restricted neoepitopes, and modulation of the CD155/TIGIT axis can promote immune evasion in PDAC. In preclinical models, a combination immunotherapy targeting TIGIT/PD-1 plus CD40 agonism has shown promising anti-tumor responses.

CANCER CELL (2021)

Article Biochemical Research Methods

Probing T-cell response by sequence-based probabilistic modeling

Barbara Bravi et al.

Summary: This research proposes a machine learning-based approach to identify antigen-specific TCRs and accurately distinguish specific TCR responses to different antigen stimulations. The model parameters and low-dimensional representations of T-cell sequences help identify sequence motifs underlying T-cell recognition at the molecular level.

PLOS COMPUTATIONAL BIOLOGY (2021)

Article Immunology

Mutation position is an important determinant for predicting cancer neoantigens

Aude-Helene Capietto et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Article Oncology

The Evolutionary Origins of Recurrent Pancreatic Cancer

Hitomi Sakamoto et al.

CANCER DISCOVERY (2020)

Article Multidisciplinary Sciences

Neoantigen-directed immune escape in lung cancer evolution

Rachel Rosenthal et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes

Erick Riquelme et al.

Article Multidisciplinary Sciences

Longitudinal molecular trajectories of diffuse glioma in adults

Floris P. Barthel et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer

Allen W. Zhang et al.

Article Oncology

Immune Cytolytic Activity Stratifies Molecular Subsets of Human Pancreatic Cancer

David Balli et al.

CLINICAL CANCER RESEARCH (2017)

Article Multidisciplinary Sciences

Quantifiable predictive features define epitope-specific T cell receptor repertoires

Pradyot Dash et al.

NATURE (2017)

Article Multidisciplinary Sciences

Identifying specificity groups in the T cell receptor repertoire

Jacob Glanville et al.

NATURE (2017)

Article Multidisciplinary Sciences

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

Vinod P. Balachandran et al.

NATURE (2017)

Article Medicine, Research & Experimental

Lack of immunoediting in murine pancreatic cancer reversed with neoantigen

Rebecca A. Evans et al.

JCI INSIGHT (2016)

Article Multidisciplinary Sciences

Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

Eliezer M. Van Allen et al.

SCIENCE (2015)

Review Multidisciplinary Sciences

Neoantigens in cancer immunotherapy

Ton N. Schumacher et al.

SCIENCE (2015)

Article Multidisciplinary Sciences

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

Naiyer A. Rizvi et al.

SCIENCE (2015)

Article Biotechnology & Applied Microbiology

PhyloWGS: Reconstructing subclonal composition and evolution from whole-genome sequencing of tumors

Amit G. Deshwar et al.

GENOME BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Deconstructing the Peptide-MHC Specificity of T Cell Recognition

Michael E. Birnbaum et al.

Article Multidisciplinary Sciences

Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

Hirokazu Matsushita et al.

NATURE (2012)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Article Multidisciplinary Sciences

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

Shinichi Yachida et al.

NATURE (2010)

Review Immunology

Cancer immunoediting: from immunosurveillance to tumor escape

GP Dunn et al.

NATURE IMMUNOLOGY (2002)