Nor-triterpenoids from the fruiting bodies of Ganoderma lucidum and their inhibitory activity against FAAH

Two new nor-triterpenoids ganodrenol A (1), B (2), and a new natural product ganodrenol C (3), along with three known nor-triterpenoids (4-6) were isolated from the fruiting bodies of Ganoderma lucidum. The chemical structures of these isolates were determined by 1 D and 2 D NMR, HRESIMS, and X-ray crystallography analysis. The inhibitory effects of isolated triterpenoids (1-6) against FAAH were evaluated by an in vitro assay, and compound 4 showed an inhibition rate of 70.27%. In addition, the cytotoxic effect of compounds (1-6) was evaluated against LOVO, MCF-7, and RAW264.7 cells, which displayed no significant cytotoxicity.

Automated summary

Two new nor-triterpenoids, ganodrenol A and B, and a new natural product, ganodrenol C, along with three known nor-triterpenoids, were isolated from the fruiting bodies of Ganoderma lucidum. The chemical structures of these compounds were determined by various analytical techniques. Compound 4 showed strong inhibition against FAAH, but exhibited no significant cytotoxicity.