期刊
NATURAL PRODUCT RESEARCH
卷 36, 期 23, 页码 6096-6100出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2022.2045984
关键词
Cousinia turkmenorum; sesquiterpene lactone; cytotoxicity; lignans
资金
- Mashhad University of Medical Sciences Research Council [910798]
This study isolated several compounds with potential anticancer activity from the aerial parts of Cousinia turkmenorum Bornm, among which aguerin B showed the strongest cytotoxicity against MCF7 cell lines.
Seven sesquiterpene lactones, chlorophyssopifolin E (1), aguerin B (2), repdiolide triol (3), solistitiolide (4), aitchisonolide (5), sinicin B (6), cynaropicrin (7), along with four lignans arctigenin (8), arctiin (9), matairesinol (10), and matairesinoside (11) were isolated for the first time from the aerial parts of Cousinia turkmenorum Bornm. Among the isolated compounds, aguerin B (2) showed the most cytotoxic activity against MCF7 cell lines with IC50 value of 18.9 mu M. Findings of this study could be useful for the development of new anticancer agents from nature.
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