相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。In Vitro Antimicrobial Activity of a Siderophore Cephalosporin, S-649266, against Enterobacteriaceae Clinical Isolates, Including Carbapenem-Resistant Strains
Naoki Kohira et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2016)
In vitro antimicrobial activity of S-649266, a catechol-substituted siderophore cephalosporin, when tested against non-fermenting Gram-negative bacteria
Akinobu Ito et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2016)
Discovery and development of surotomycin for the treatment of Clostridium difficile
Victoria Knight-Connoni et al.
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2016)
Impact of Surotomycin on the Gut Microbiota of Healthy Volunteers in a Phase 1 Clinical Trial
Diane M. Citron et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2016)
Alternatives to antibiotics-a pipeline portfolio review
Lloyd Czaplewski et al.
LANCET INFECTIOUS DISEASES (2016)
Ceftolozane/Tazobactam: A New Cephalosporin and β-Lactamase Inhibitor Combination
Allana J. Sucher et al.
ANNALS OF PHARMACOTHERAPY (2015)
Structure-Activity Relationship of the Aminomethylcyclines and the Discovery of Omadacycline
Laura Honeyman et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
Eravacycline (TP-434) Is Active In Vitro against Biofilms Formed by Uropathogenic Escherichia coli
Trudy H. Grossman et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
In Vitro Activity of Ceftolozane Alone and in Combination with Tazobactam against Extended-Spectrum-β-Lactamase-Harboring Enterobacteriaceae
Maria J. B. Melchers et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
Pharmacodynamic Profile of GSK2140944 against Methicillin-Resistant Staphylococcus aureus in a Murine Lung Infection Model
Wonhee So et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
High Efficacy of Finafloxacin on Helicobacter pylori Isolates at pH 5.0 Compared with That of Other Fluoroquinolones
Jung Won Lee et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
Mode of Action and Bactericidal Properties of Surotomycin against Growing and Nongrowing Clostridium difficile
Mohammed Zahidul Alam et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
Effects of Surotomycin on Clostridium difficile Viability and Toxin Production In Vitro
Laurent Bouillaut et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
Activity of Debio1452, a FabI Inhibitor with Potent Activity against Staphylococcus aureus and Coagulase-Negative Staphylococcus spp., Including Multidrug-Resistant Strains
Robert K. Flamm et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
In Vivo Activities of Simulated Human Doses of Cefepime and Cefepime-AAI101 against Multidrug-Resistant Gram-Negative Enterobacteriaceae
Jared L. Crandon et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
SQ109, a New Drug Lead for Chagas Disease
Phercyles Veiga-Santos et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
Mutations in Genes for the F420 Biosynthetic Pathway and a Nitroreductase Enzyme Are the Primary Resistance Determinants in Spontaneous In Vitro-Selected PA-824-Resistant Mutants of Mycobacterium tuberculosis
Hana L. Haver et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
Tedizolid: The First Once-Daily Oxazolidinone Class Antibiotic
Steven D. Burdette et al.
CLINICAL INFECTIOUS DISEASES (2015)
Editorial overview: Anti-infectives: Current challenges and unmet needs in antimicrobial therapy
Federico Pea
CURRENT OPINION IN PHARMACOLOGY (2015)
The global challenge of new classes of antibacterial agents: an industry perspective
Prabhavathi Fernandes
CURRENT OPINION IN PHARMACOLOGY (2015)
Tedizolid: A Novel Oxazolidinone with Potent Activity Against Multidrug-Resistant Gram-Positive Pathogens
George G. Zhanel et al.
DRUGS (2015)
Plazomicin: an investigational therapy for the treatment of urinary tract infections
Ilias Karaiskos et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2015)
Safety, tolerability and pharmacokinetics of AFN-1252 administered as immediate release tablets in healthy subjects
Barry Hafkin et al.
FUTURE MICROBIOLOGY (2015)
Delafloxacin, a non-zwitterionic fluoroquinolone in Phase III of clinical development: evaluation of its pharmacology, pharmacokinetics, pharmacodynamics and clinical efficacy
Francoise Van Bambeke
FUTURE MICROBIOLOGY (2015)
In vitro bactericidal activity of aminoglycosides, including the next-generation drug plazomicin, against Brucella spp.
Steven C. Olsen et al.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2015)
The new tuberculosis drug Perchlozone® shows cross-resistance with thiacetazone
Pooja Gopal et al.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2015)
OP0595, a new diazabicyclooctane: mode of action as a serine β-lactamase inhibitor, antibiotic and β-lactam 'enhancer'
Akihiro Morinaka et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2015)
Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914
Gunther Kern et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Structure-Activity Relationship Studies of a Series of Semisynthetic Lipopeptides Leading to the Discovery of Surotomycin, a Novel Cyclic Lipopeptide Being Developed for the Treatment of Clostridium difficile-Associated Diarrhea
Ning Yin et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Ceftolozane-tazobactam compared with levofloxacin in the treatment of complicated urinary-tract infections, including pyelonephritis: a randomised, double-blind, phase 3 trial (ASPECT-cUTI)
Florian M. Wagenlehner et al.
LANCET (2015)
A new antibiotic kills pathogens without detectable resistance (vol 517, pg 455, 2015)
Losee L. Ling et al.
NATURE (2015)
A community-based approach to new antibiotic discovery
Matthew A. Cooper
NATURE REVIEWS DRUG DISCOVERY (2015)
ESKAPEing the labyrinth of antibacterial discovery
Ruben Tommasi et al.
NATURE REVIEWS DRUG DISCOVERY (2015)
Antibiotic resistance breakers: can repurposed drugs fill the antibiotic discovery void?
David Brown
NATURE REVIEWS DRUG DISCOVERY (2015)
Delamanid for Extensively Drug-Resistant Tuberculosis
Rajesh Gupta et al.
NEW ENGLAND JOURNAL OF MEDICINE (2015)
Preface
Roy M. Anderson
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2015)
Surveillance of antibiotic resistance
Alan P. Johnson
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2015)
Tackling the threat of antimicrobial resistance: from policy to sustainable action
Laura J. Shallcross et al.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2015)
Antimicrobial resistance in humans, livestock and the wider environment
Mark Woolhouse et al.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2015)
The livestock reservoir for antimicrobial resistance: a personal view on changing patterns of risks, effects of interventions and the way forward
Frank M. Aarestrup
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2015)
AFN-1252 is a potent inhibitor of enoyl-ACP reductase from Burkholderia pseudomallei-Crystal structure, mode of action, and biological activity
Krishnamurthy Narasimha Rao et al.
PROTEIN SCIENCE (2015)
THE DRUG PUSH As fears of drug-resistant bacteria loom, governments try to coax companies back to the field
Kelly Servick
SCIENCE (2015)
Nonmedical Uses of Antibiotics: Time to Restrict Their Use?
Richard William Meek et al.
PLOS BIOLOGY (2015)
Oxa, Thia, Heterocycle, and Carborane Analogues of SQ109: Bacterial and Protozoal Cell Growth Inhibitors
Kai Li et al.
ACS INFECTIOUS DISEASES (2015)
Helping Chemists Discover New Antibiotics
Mark A. T. Blaskovich et al.
ACS INFECTIOUS DISEASES (2015)
In Vitro and In Vivo Activities of the Nitroimidazole TBA-354 against Mycobacterium tuberculosis
A. M. Upton et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
Contribution of the Nitroimidazoles PA-824 and TBA-354 to the Activity of Novel Regimens in Murine Models of Tuberculosis
Rokeya Tasneen et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
LTX-109 Is a Novel Agent for Nasal Decolonization of Methicillin-Resistant and -Sensitive Staphylococcus aureus
Anna C. Nilsson et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
Delamanid: A Review of Its Use in Patients with Multidrug-Resistant Tuberculosis
Hannah A. Blair et al.
DRUGS (2015)
The potential role of nemonoxacin for treatment of common infections
Chung-Hao Huang et al.
EXPERT OPINION ON PHARMACOTHERAPY (2015)
In Vitro Activity of Cefepime/AAI101 and Comparators against Cefepime Non-susceptible Enterobacteriaceae
Jared L. Crandon et al.
PATHOGENS (2015)
Therapeutic strategies to combat antibiotic resistance
Benjamin D. Brooks et al.
ADVANCED DRUG DELIVERY REVIEWS (2014)
In Vitro Activity of Nemonoxacin, a Novel Nonfluorinated Quinolone Antibiotic, against Chlamydia trachomatis and Chlamydia pneumoniae
Kobkui Chotikanatis et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
In Vitro Activity of Solithromycin against Erythromycin-Resistant Streptococcus agalactiae
Giorgio Piccinelli et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
Investigations of the Mode of Action and Resistance Development of Cadazolid, a New Antibiotic for Treatment of Clostridium difficile Infections
Hans H. Locher et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
In Vitro and In Vivo Antibacterial Evaluation of Cadazolid, a New Antibiotic for Treatment of Clostridium difficile Infections
Hans H. Locher et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
In Vitro and In Vivo Antibacterial Activities of Omadacycline, a Novel Aminomethylcycline
A. B. Macone et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
Mechanism of Action of the Novel Aminomethylcycline Antibiotic Omadacycline
Michael P. Draper et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
Novel Insights into the Mechanism of Inhibition of MmpL3, a Target of Multiple Pharmacophores in Mycobacterium tuberculosis
Wei Li et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
In Vivo Antibacterial Activity of MRX-I, a New Oxazolidinone
Cong-Ran Li et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
In Vitro Activity of the New Fluoroketolide Solithromycin (CEM-101) against Macrolide-Resistant and -Susceptible Mycoplasma genitalium Strains
Jorgen Skov Jensen et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
Multicenter, Double-Blind, Randomized, Phase II Trial To Assess the Safety and Efficacy of Ceftolozane-Tazobactam plus Metronidazole Compared with Meropenem in Adult Patients with Complicated Intra-Abdominal Infections
Christopher Lucasti et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
Carbapenem-Resistant Klebsiella pneumoniae Strains Exhibit Diversity in Aminoglycoside-Modifying Enzymes, Which Exert Differing Effects on Plazomicin and Other Agents
Reem Almaghrabi et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
In Vitro Activity of Plazomicin against 5,015 Gram-Negative and Gram- Positive Clinical Isolates Obtained from Patients in Canadian Hospitals as Part of the CANWARD Study, 2011-2012
A. Walkty et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
High In Vitro Activity of the Novel Spiropyrimidinetrione AZD0914, a DNA Gyrase Inhibitor, against Multidrug-Resistant Neisseria gonorrhoeae Isolates Suggests a New Effective Option for Oral Treatment of Gonorrhea
Susanne Jacobsson et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
Confronting the challenges of discovery of novel antibacterial agents
Sheo B. Singh
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)
Update on the antibiotic resistance crisis
Gian Maria Rossolini et al.
CURRENT OPINION IN PHARMACOLOGY (2014)
In vitro activity of the siderophore monosulfactam BAL30072 against contemporary Gram-negative pathogens from New York City, including multidrug-resistant isolates
David Landman et al.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2014)
Selection and characterisation of Staphylococcus aureus mutants with reduced susceptibility to the investigational oxazolidinone MRX-I
Yanqin Huang et al.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2014)
Prospects for new antibiotics: a molecule-centered perspective
Christopher T. Walsh et al.
JOURNAL OF ANTIBIOTICS (2014)
Glycopeptide antibiotics: Back to the future
Mark S. Butler et al.
JOURNAL OF ANTIBIOTICS (2014)
Determination of Disk Diffusion and MIC Quality Control Guidelines for GSK2140944, a Novel Bacterial Type II Topoisomerase Inhibitor Antimicrobial Agent
James E. Ross et al.
JOURNAL OF CLINICAL MICROBIOLOGY (2014)
Lead Optimization of a Novel Series of Imidazo[1,2-a]pyridine Amides Leading to a Clinical Candidate (Q203) as a Multi- and Extensively-Drug-Resistant Anti-tuberculosis Agent
Sunhee Kang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
New Potent Antibacterial Oxazolidinone (MRX-I) with an Improved Class Safety Profile
Mikhail F. Gordeev et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Antibiotic resistance sweeping developing world
Sara Reardon
NATURE (2014)
Fraunhofer to mine Sanofi microbial collection
Jeffrey L. Fox
NATURE BIOTECHNOLOGY (2014)
Second MRSA antibiotic reaches the market
Jeffrey L. Fox
NATURE BIOTECHNOLOGY (2014)
Anti-cooperative ligand binding and dimerisation in the glycopeptide antibiotic dalbavancin
Mu Cheng et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2014)
The antimicrobial resistance crisis: causes, consequences, and management
Carolyn Anne Michael et al.
FRONTIERS IN PUBLIC HEALTH (2014)
Absorption, Distribution, Metabolism, and Excretion of the Novel Antibacterial Prodrug Tedizolid Phosphate
Voon Ong et al.
DRUG METABOLISM AND DISPOSITION (2014)
β-Lactam Antibiotics Renaissance
Wenling Qin et al.
ANTIBIOTICS-BASEL (2014)
In vitro activity of cadazolid against Clostridium difficile strains isolated from primary and recurrent infections in Stockholm, Sweden
Mamun-Ur Rashid et al.
ANAEROBE (2013)
Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials
Kieron M. G. O'Connell et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
New β-lactam-β-lactamase inhibitor combinations in clinical development
David M. Shlaes
ANTIMICROBIAL THERAPEUTICS REVIEWS: THE BACTERIAL CELL WALL AS AN ANTIMICROBIAL TARGET (2013)
NVC-422 Inactivates Staphylococcus aureus Toxins
Andreas Jekle et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)
Involvement of Fe Uptake Systems and AmpC β-Lactamase in Susceptibility to the Siderophore Monosulfactam BAL30072 in Pseudomonas aeruginosa
Christian van Delden et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)
Phase II Clinical Study of BC-3781, a Pleuromutilin Antibiotic, in Treatment of Patients with Acute Bacterial Skin and Skin Structure Infections
W. T. Prince et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)
In Vitro Activity of Ozenoxacin against Quinolone-Susceptible and Quinolone-Resistant Gram-Positive Bacteria
Y. Lopez et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)
Human Simulated Studies of Aztreonam and Aztreonam-Avibactam To Evaluate Activity against Challenging Gram-Negative Organisms, Including Metallo-β-Lactamase Producers
Jared L. Crandon et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)
N-Chloramines, a Promising Class of Well-Tolerated Topical Anti-Infectives
Waldemar Gottardi et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)
Perturbation of Staphylococcus aureus Gene Expression by the Enoyl-Acyl Carrier Protein Reductase Inhibitor AFN-1252
Joshua B. Parsons et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)
Solithromycin Inhibition of Protein Synthesis and Ribosome Biogenesis in Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae
Ward Rodgers et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)
Antibacterial Activity of Eravacycline (TP-434), a Novel Fluorocycline, against Hospital and Community Pathogens
J. A. Sutcliffe et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)
Locations of the Hydrophobic Side Chains of Lipoglycopeptides Bound to the Peptidoglycan of Staphylococcus aureus
Sung Joon Kim et al.
BIOCHEMISTRY (2013)
Fungicidal photodynamic effect of a twofold positively charged porphyrin against Candida albicans planktonic cells and biofilms
Fernanda Pereira Gonzales et al.
FUTURE MICROBIOLOGY (2013)
Tedizolid Phosphate vs Linezolid for Treatment of Acute Bacterial Skin and Skin Structure Infections The ESTABLISH-1 Randomized Trial
Philippe Prokocimer et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)
Speculative strategies for new antibacterials: all roads should not lead to Rome
Stuart Shapiro
JOURNAL OF ANTIBIOTICS (2013)
Antibiotics in the clinical pipeline in 2013
Mark S. Butler et al.
JOURNAL OF ANTIBIOTICS (2013)
Activity of biapenem (RPX2003) combined with the boronate -lactamase inhibitor RPX7009 against carbapenem-resistant Enterobacteriaceae
David M. Livermore et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2013)
Combined effects of the siderophore monosulfactam BAL30072 and carbapenems on multidrug-resistant Gram-negative bacilli
Beatrice Hofer et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2013)
Activity of AFN-1252, a novel FabI inhibitor, against Staphylococcus aureus in an in vitro pharmacodynamic model simulating human pharmacokinetics
Brian T. Tsuji et al.
JOURNAL OF CHEMOTHERAPY (2013)
In vitro activity (MICs and rate of kill) of AFN-1252, a novel FabI inhibitor, in the presence of serum and in combination with other antibiotics
Nachum Kaplan et al.
JOURNAL OF CHEMOTHERAPY (2013)
Pharmacokinetics, pharmacodynamics and efficacy of novel FabI inhibitor AFN-1252 against MSSA and MRSA in the murine thigh infection model
Mary A. Banevicius et al.
JOURNAL OF CHEMOTHERAPY (2013)
BARDA to pick and choose next-generation antibiotics
Gunjan Sinha
NATURE BIOTECHNOLOGY (2013)
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis
Kevin Pethe et al.
NATURE MEDICINE (2013)
Process R&D of Eravacycline: The First Fully Synthetic Fluorocycline in Clinical Development
Magnus Ronn et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2013)
Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products
Jeremy G. Owen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Sources of Antimicrobial Resistance
Mark E. J. Woolhouse et al.
SCIENCE (2013)
A Novel Macrolide Solithromycin Exerts Superior Anti-inflammatory Effect via NF-κB Inhibition
Yoshiki Kobayashi et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2013)
Antistaphylococcal Activity of TD-1792, a Multivalent Glycopeptide-Cephalosporin Antibiotic
Johanne Blais et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
In Vitro Activities of CB-183,315, Vancomycin, and Metronidazole against 556 Strains of Clostridium difficile, 445 Other Intestinal Anaerobes, and 56 Enterobacteriaceae Species
Diane M. Citron et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
In Vitro Activities of LTX-109, a Synthetic Antimicrobial Peptide, against Methicillin-Resistant, Vancomycin-Intermediate, Vancomycin-Resistant, Daptomycin-Nonsusceptible, and Linezolid-Nonsusceptible Staphylococcus aureus
Louis D. Saravolatz et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
TD-1792 versus Vancomycin for Treatment of Complicated Skin and Skin Structure Infections
Martin E. Stryjewski et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Activity of a Novel Cyclic Lipopeptide, CB-183,315, against Resistant Clostridium difficile and Other Gram-Positive Aerobic and Anaerobic Intestinal Pathogens
D. R. Snydman et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
In Vitro Activity of the New Fluoroketolide Solithromycin (CEM-101) against a Large Collection of Clinical Neisseria gonorrhoeae Isolates and International Reference Strains, Including Those with High-Level Antimicrobial Resistance: Potential Treatment Option for Gonorrhea?
Daniel Golparian et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Antimicrobial Activity of the Investigational Pleuromutilin Compound BC-3781 Tested against Gram-Positive Organisms Commonly Associated with Acute Bacterial Skin and Skin Structure Infections
Helio S. Sader et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Mode of Action, In Vitro Activity, and In Vivo Efficacy of AFN-1252, a Selective Antistaphylococcal FabI Inhibitor
Nachum Kaplan et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Target- and Resistance-Based Mechanistic Studies with TP-434, a Novel Fluorocycline Antibiotic
Trudy H. Grossman et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Oritavancin: Mechanism of Action
George G. Zhanel et al.
CLINICAL INFECTIOUS DISEASES (2012)
Comparison of the next-generation aminoglycoside plazomicin to gentamicin, tobramycin and amikacin
George G. Zhanel et al.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2012)
Substrate specificity of the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis responsible for the bioreductive activation of bicyclic nitroimidazoles
Meera Gurumurthy et al.
FEBS JOURNAL (2012)
In vitro activity of tedizolid (TR-700) against linezolid-resistant staphylococci
Iciar Rodriguez-Avial et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2012)
Antimicrobial activity of the novel pleuromutilin antibiotic BC-3781 against organisms responsible for community-acquired respiratory tract infections (CARTIs)
Helio S. Sader et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2012)
In vitro activity of the siderophore monosulfactam BAL30072 against meropenem-non-susceptible Acinetobacter baumannii
Paul G. Higgins et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2012)
Activity of Plazomicin (ACHN-490) against MDR clinical isolates of Klebsiella pneumoniae, Escherichia coli, and Enterobacter spp. from Athens, Greece
Irene Galani et al.
JOURNAL OF CHEMOTHERAPY (2012)
Fluorocyclines. 2. Optimization of the C-9 Side-Chain for Antibacterial Activity and Oral Efficacy
Roger B. Clark et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Fluorocyclines. 1. 7-Fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline: A Potent, Broad Spectrum Antibacterial Agent
Xiao-Yi Xiao et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor
David E. Ehmann et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Are pleuromutilin antibiotics finally fit for human use?
Rodger Novak
ANTIMICROBIAL THERAPEUTICS REVIEWS: ANTIBIOTICS THAT TARGET THE RIBOSOME (2011)
Investigation of the Potential for Mutational Resistance to XF-73, Retapamulin, Mupirocin, Fusidic Acid, Daptomycin, and Vancomycin in Methicillin-Resistant Staphylococcus aureus Isolates during a 55-Passage Study
David J. Farrell et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
Contrasting Effects of Acidic pH on the Extracellular and Intracellular Activities of the Anti-Gram-Positive Fluoroquinolones Moxifloxacin and Delafloxacin against Staphylococcus aureus
Sandrine Lemaire et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
In Vitro Spectrum of Activity of Finafloxacin, a Novel, pH-Activated Fluoroquinolone, under Standard and Acidic Conditions
Will Stubbings et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
Diazabicyclooctanes (DBOs): a potent new class of non-β-lactam β-lactamase inhibitors
Ken Coleman
CURRENT OPINION IN MICROBIOLOGY (2011)
Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent
Weon Bin Im et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
In vitro activity of BAL30072 against Burkholderia pseudomallei
Takehiko Mima et al.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2011)
Antimicrobial characterisation of solithromycin (CEM-101), a novel fluoroketolide: activity against staphylococci and enterococci
Shannon D. Putnam et al.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2011)
In vitro susceptibilities of clinical isolates of ertapenem-non-susceptible Enterobacteriaceae to nemonoxacin, tigecycline, fosfomycin and other antimicrobial agents
Meng-Shuian Hsu et al.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2011)
Antibiotics in the clinical pipeline in 2011
Mark S. Butler et al.
JOURNAL OF ANTIBIOTICS (2011)
A Synthetic Antimicrobial Peptidomimetic (LTX 109): Stereochemical Impact on Membrane Disruption
Johan Isaksson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Fix the antibiotics pipeline
Matthew A. Cooper et al.
NATURE (2011)
A Concise Synthesis of a β-Lactamase Inhibitor
Ian K. Mangion et al.
ORGANIC LETTERS (2011)
De Novo Design of Antimicrobial Polymers, Foldamers, and Small Molecules: From Discovery to Practical Applications
Gregory N. Tew et al.
ACCOUNTS OF CHEMICAL RESEARCH (2010)
In Vitro and In Vivo Activities of LCB01-0371, a New Oxazolidinone
Ji-Woong Jeong et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Mechanistic Studies of the Inactivation of TEM-1 and P99 by NXL104, a Novel Non-β-Lactam β-Lactamase Inhibitor
Therese Stachyra et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Comparative In Vitro Activities of Nemonoxacin (TG-873870), a Novel Nonfluorinated Quinolone, and Other Quinolones against Clinical Isolates
Tsai-Ling Lauderdale et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Oritavancin Disrupts Membrane Integrity of Staphylococcus aureus and Vancomycin-Resistant Enterococci To Effect Rapid Bacterial Killing
Adam Belley et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
In Vitro Properties of BAL30072, a Novel Siderophore Sulfactam with Activity against Multiresistant Gram-Negative Bacilli
Malcolm G. P. Page et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Synthesis and Spectrum of the Neoglycoside ACHN-490
James B. Aggen et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
New Lipoglycopeptides A Comparative Review of Dalbavancin, Oritavancin and Telavancin
George G. Zhanel et al.
DRUGS (2010)
Oritavancin: a novel lipoglycopeptide active against Gram-positive pathogens including multiresistant strains
Emilio Bouza et al.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2010)
In vitro activity of XF-73, a novel antibacterial agent, against antibiotic-sensitive and -resistant Gram-positive and Gram-negative bacterial species
David J. Farrell et al.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2010)
XF-70 and XF-73, novel antibacterial agents active against slow-growing and non-dividing cultures of Staphylococcus aureus including biofilms
Nicola Ooi et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2010)
Activity of the siderophore monobactam BAL30072 against multiresistant non-fermenters
Shazad Mushtaq et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2010)
Antibacterial activity of finafloxacin under different pH conditions against isogenic strains of Escherichia coli expressing combinations of defined mechanisms of fluoroquinolone resistance
Nadine-C. Emrich et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2010)
The in vitro evaluation of solithromycin (CEM-101) against pathogens isolated in the United States and Europe (2009)
David J. Farrell et al.
JOURNAL OF INFECTION (2010)
A Comparative Review of the Lipoglycopeptides: Oritavancin, Dalbavancin, and Telavancin
Michael T. Guskey et al.
PHARMACOTHERAPY (2010)
Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa
Nityakalyani Srinivas et al.
SCIENCE (2010)
In Vitro Activity of the Quinolone WCK 771 against Recent US Hospital and Community-Acquired Staphylococcus aureus Pathogens with Various Resistance Types
Sachin S. Bhagwat et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
AFN-1252, a FabI Inhibitor, Demonstrates a Staphylococcus-Specific Spectrum of Activity
James A. Karlowsky et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
Novel Ribosomal Mutations in Staphylococcus aureus Strains Identified through Selection with the Oxazolidinones Linezolid and Torezolid (TR-700)
Jeffrey B. Locke et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
Stieglitz rearrangement of N,N-dichloro-β,β-disubstituted taurines under mild aqueous conditions
Timothy P. Shiau et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Quaternary ammonium N,N-dichloroamines as topical, antimicrobial agents
Charles Francavilla et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Quinolones: Action and Resistance Updated
Karl Drlica et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2009)
XF-73, a novel antistaphylococcal membrane-active agent with rapid bactericidal activity
Nicola Ooi et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2009)
Spectrum of activity and mode of action of REP3123, a new antibiotic to treat Clostridium difficile infections
Ian A. Critchley et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2009)
Vancomycin and Oritavancin Have Different Modes of Action in Enterococcus faecium
Gary J. Patti et al.
JOURNAL OF MOLECULAR BIOLOGY (2009)
Crystal structures of pyridine-4-aldehyde thiosemicarbazone perchlorate and trifluoromethane sulfonate
A. I. Smolentsev et al.
JOURNAL OF STRUCTURAL CHEMISTRY (2009)
De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers
Sungwook Choi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Inhibitors of Fabl, an enzyme drug target in the bacterial fatty acid biosynthesis pathway
Hao Lu et al.
ACCOUNTS OF CHEMICAL RESEARCH (2008)
In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens
Laura Lawrence et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)
Rχ-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance
Eugene Skripkin et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)
Design at the atomic level: Design of biaryloxazolidinones as potent orally active antibiotics
Jiacheng Zhou et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Synthesis and SAR of novel parenteral anti-pseudomonal cephalosporins: Discovery of FR264205
Ayako Toda et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Design at the atomic level: Generation of novel hybrid biaryloxazolidinones as promising new antibiotics
Jiacheng Zhou et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Antimicrobial activities of twenty lysine-peptoid hybrids against clinically relevant bacteria and fungi
Trine S. Ryge et al.
CHEMOTHERAPY (2008)
Adis drug profile - Dalbavancin
Vanessa R. Anderson et al.
DRUGS (2008)
Oritavancin exhibits dual mode of action to inhibit cell-wall biosynthesis, in Staphylococcus aureus
Sung Joon Kim et al.
JOURNAL OF MOLECULAR BIOLOGY (2008)
PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release
Ramandeep Singh et al.
SCIENCE (2008)
N-Chloro-2,2-dimethyltaurines:: a new class of remarkably stable N-chlorotaurines
Lu Wang et al.
TETRAHEDRON LETTERS (2008)
Antimicrobial lexitropsins containing amide, amidine, and alkene linking groups
Nahoum G. Anthony et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
In vitro and in vivo activities of a new cephalosporin, FR264205, against Pseudomonas aeruginosa
Shinobu Takeda et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)
In vitro activity of API-1252, a novel FabI inhibitor, against clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis
James A. Karlowsky et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)
Drugs for bad bugs: confronting the challenges of antibacterial discovery
David J. Payne et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
Synthesis and antituberculosis activity of a novel series of optically active 6-nitro-2,3-dihydroimidazo[2,1-b]oxazoles
Hirofumi Sasaki et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Two decades of imipenem therapy
A. C. Rodloff et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2006)
OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice
Makoto Matsumoto et al.
PLOS MEDICINE (2006)
Nadifloxacin: a quinolone for topical treatment of skin infections and potential for systemic use of its active isomer, WCK 771
Michael R. Jacobs et al.
EXPERT OPINION ON PHARMACOTHERAPY (2006)
Activity of the new quinolones WCK 771, WCK 1152 and WCK 1153 against clinical isolates of Streptococcus pneumoniae and Streptococcus pyogenes
A Al-Lahham et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2005)
Effect of pH on the in vitro activity of and propensity for emergence of resistance to fluoroquinolones, macrolides, and a ketolide
A Dalhoff et al.
INFECTION (2005)
A chiral benzoquinolizine-2-carboxylic acid arginine salt active against vancomycin-resistant Staphylococcus aureus
NJ de Souza et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Photodynamic effects of novel XF porphyrin derivatives on prokaryotic and eukaryotic cells
T Maisch et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)
In vitro activity of AVE1330A, an innovative broad-spectrum non-β-lactam β-lactamase inhibitor
A Bonnefoy et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2004)
Combinatorial lead optimization of [1,2]-diamines based on ethambutol as potential antituberculosis preclinical candidates
RE Lee et al.
JOURNAL OF COMBINATORIAL CHEMISTRY (2003)
Discovery of a novel and potent class of fabI-directed antibacterial agents
DJ Payne et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2002)
In vitro and in vivo antibacterial activity of T-3912, a novel non-fluorinated topical quinolone
T Yamakawa et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2002)
A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis
CK Stover et al.
NATURE (2000)
分享论文
