期刊
NANO TODAY
卷 44, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2022.101476
关键词
DNA allostery; Logic gates; Silver nanoclusters; Catalytic activity; Biomarkers
资金
- National Key R&D Program of China [2020YFB2009004, 2019YFA0709202]
- National Natural Science Foundation of China [22004119]
- Youth Innovation Promotion Association CAS [2021224]
This work presents the exquisite logic manipulation of nanometallic catalysis of DNA-templated silver nanoclusters (DNA-AgNCs) based on designative input-responsive DNA allostery and distinct inhibition effects of duplexes and triplexes on catalytic activity. A series of molecular logic gates are introduced, capable of controlling the catalytic activity of DNA-AgNCs in logic manners. The importance of this study lies in the intelligent detection of significant disease biomarkers using a low-cost and universal platform.
This work reports exquisite logic manipulation of nanometallic catalysis of DNA-templated silver nanoclusters (DNA-AgNCs) based on designative input-responsive DNA allostery and distinct inhibition effects of duplexes and triplexes on catalytic activity. A series of molecular logic gates (YES, OR, INHIBIT, XOR and MAJORITY) are presented, which are capable to control the catalytic activity of DNA-AgNCs in logic manners. Distinct from most of previous DNA-AgNC-based logic gates, its catalytic effect is adopted as the output signal instead of variable fluorescence, which offers a novel and robust approach for fabrication of molecular logic gate. One of the logic systems performs multiple bioanalysis of cardiac biomarkers (cardiac troponin I and myoglobin). Hence, it is worthwhile to anticipate intelligent detection of more significant disease biomarkers will be attained with the low-cost and universal platform. Moreover, the integration of programmable DNA reaction and aptamer recognition endows DNA-AgNCs catalytic specificity, which will give us hints how to devise smart DNA-functionalized nanomaterials.(c) 2022 Elsevier Ltd. All rights reserved.
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