期刊
NANO RESEARCH
卷 15, 期 6, 页码 5262-5272出版社
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-022-4165-1
关键词
mesoporous polydopamine; chemodynamic therapy; glucose oxidase; Fenton reaction; synergistic efficacy
类别
资金
- National Key Research and Development Projects Intergovernmental Cooperation in Science and Technology of China [2018YFE0126900]
- National Natural Science Foundation of China [82072026, 81901852, 81901848]
- National Natural Science Foundation of Zhejiang Province [LQ21H180003, LY21H160010]
- Medical and Health Science and Technology Plan Project of Zhejiang Province [2021KY414, 2020RC042]
- Key R&D Program of Lishui City [2021ZDYF12]
This study developed a novel nanomedicine platform for cancer therapy, combining MRI-guided photothermal therapy and enhanced chemodynamic therapy. It achieved more effective treatment by modulating the microenvironment, generating heat, and enhancing the efficacy of chemodynamic therapy.
Traditional anticancer treatments fail to significantly improve prognoses, and exploration of novel promising therapeutic modalities is urgently needed. In this study, multifunctional mesoporous polydopamine nanoparticles (Pt@MPDA/GOx/Fe3+ NPs) loaded with glucose oxidase (GOx), Fe ions and ultrasmall Pt nanoparticles (NPs) were prepared for magnetic resonance imaging (MRI)-guided photothermal therapy (PTT)-enhanced chemodynamic therapy (CDT). The oxidation of intratumoral glucose to H2O2 and GOx induced an H2O2-rich microenvironment, and then elevated H2O2 was catalyzed into highly cytotoxic center dot OH by Fe(3+)via a Fenton reaction for CDT to induce cancer cell death efficiently. Notably, the heat generated by MPDA NPs under laser irradiation offered a moderate PTT to cascade the CDT effect. Moreover, Pt NPs can oxidize H2O2 to yield O-2, which in turn accelerates the catalytic process of GOx to increase the efficiency of CDT. Meanwhile, in the high oxidation environment of tumor cells, Pt NPs are oxidized into Pt2+ to achieve a tumor chemotherapy effect. In addition, chelated Fe3+ endows the system with an MRI-visible function to monitor the treatment efficacy. In conclusion, this study provides a novel MRI-guided PTT-enhanced CDT synergistic nanomedicine platform for cancer therapy.
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