期刊
NANO RESEARCH
卷 15, 期 8, 页码 7295-7303出版社
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-022-4332-4
关键词
drug delivery system; calixarene; host-guest interaction; hypoxia-responsiveness; drug tracking
类别
资金
- National Key Research and Development Programs of China [2018YFA0209700]
- National Natural Science Foundation of China (NSFC) [22077073]
- Frontiers Science Center for New Organic Matter [63181206]
- Fundamental Research Funds for the Central Universities (Nankai University) [63206015]
A calixarene-integrated nano-drug delivery system (CanD) is developed for tumor-targeted delivery and tracking of anti-cancer drugs, resulting in enhanced tumor suppression in vivo.
Nano-drug delivery systems (nanoDDS) have been extensively investigated clinically to improve the therapeutic effect of anti-cancer drugs. However, the complicated synthesis during the preparation as well as the potential drug leakage during transportation has greatly limited their general application. In this work, a calixarene-integrated nanoDDS (CanD) that achieves tumor-targeted delivery and tracking of anti-cancer drugs in vivo is presented. The hypoxia-responsive calixarene (SAC4A) exhibits high binding affinity to a series of anti-cancer drugs and rhodamine B (RhB) under normoxic condition while decreasing the binding affinity under hypoxic condition, which leads to the drug release and fluorescence recovery simultaneously. Furthermore, the hypoxia-responsiveness of SAC4A conveys CanD with tumor-targeting ability, resulting in the enrichment of the drug in tumors and enhancement in tumor suppression in mice. Moreover, CanD could become a general platform allowing the delivery of a wide scope of anti-cancer drugs that have strong host-guest interaction with SAC4A.
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