期刊
NANO RESEARCH
卷 15, 期 6, 页码 5556-5568出版社
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-022-4160-6
关键词
antibacterial materials; bioactive materials; hollow nanospheres; ionic liquids; porous polymers
类别
资金
- Shanghai Sailing Program [21YF1431000]
- National Research Foundation of Korea - Korean government (MSIT) [2021R1A2C2003685]
- National Research Foundation of Korea [2021R1A2C2003685] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The newly developed HPN-ILs exhibit uniform hollow spherical morphology, adequate surface area, and excellent physicochemical stability. They show high activity against both Gram-positive and Gram-negative bacteria with typical time/dosage-dependent antibacterial activities.
The design of stable, efficient and processable bactericidal materials represents a significant challenge for combating multidrug-resistant bacteria in a variety of engineering fields. Herein, we report a facile strategy for the preparation of hollow polymeric nanosphere (HPN)-supported imidazolium-based ionic liquids (denoted as HPN-ILs) with superior antimicrobial activities. HPN-ILs were tailored by moderate Friedel-Crafts polymerization followed by the sequential covalent bonding of imidazole and bromoalkene. The resultant HPN-ILs have uniform hollow spherical morphology, an adequate surface area, and excellent physicochemical stability. Furthermore, they are highly active against both Gram-positive and Gram-negative bacteria and exhibit typical time/dosage-dependent antibacterial activities. The rational combination of porous HPNs and antibacterial ILs to generate an all-in-one entity may open new avenues for the design and fabrication of efficient bacteriostatic agents. Moreover, HPN-ILs have good biocompatibility and can also be loaded onto diverse matrices, and thus could extend their practical bactericidal application in the potential biomedical-active field.
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