期刊
NANO LETTERS
卷 22, 期 7, 页码 2691-2701出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.1c04531
关键词
NIR-IIb emissive lanthanide nanoprobe; high-resolution bone imaging; bone marrow imaging; bone fracture diagnosis
类别
资金
- National Natural Science Foundation of China [22175062, 21671064]
- Scientific Research Fund of Hunan Provincial Education Department [19A329]
- Furong Scholars Programme of Hunan Province
This article reports poly(acrylic acid)-modified NaLuF4:Yb/Er/Gd/Ce@NaYF4 nanoparticles for high-resolution bone/bone marrow imaging and bone fracture diagnosis. The nanoparticles exhibit second near-infrared emission beyond 1500 nm, providing a high signal to noise ratio for accurate imaging and diagnosis of bone-related diseases.
Bones play vital roles in human health. Noninvasive visualization of the full extent of bones is highly demanded to evaluate many bone-related diseases. Herein, we report poly (acrylic acid) (PAA)-modified NaLuF4:Yb/Er/Gd/Ce@NaYF4 nanoparticles (PAA-Er) with second near-infrared emission beyond 1500 nm (also referred as NIR-IIb) for high-resolution bone/bone marrow imaging and bone fracture diagnosis. The NIR-IIb optical-guided bone marrow imaging presents a high signal to noise ratio, which is superior to that for imaging in the NIR-II window (1000-1400 nm, NIR-IIa). Importantly, we also investigated the size-dependent accumulation of the nanoparticles and the possible accumulation mechanism of the designed PAA-Er nanoprobes in bone marrow. Due to the high affinity capability of the PAA-Er nanoprobes, a highly sensitive NIR-IIb optical-guided bone fracture diagnosis was successfully achieved. This novel technology paves the way to design lanthanide nanoprobes for NIR-IIb optical-guided high-resolution bone marrow imaging and bone-related disease diagnosis.
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