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An Exponential Rather Than Multistep Model of Parkinson's Disease Pathogenesis

MOVEMENT DISORDERS (2022)

Senescent cells and the incidence of age-related diseases

Itay Katzir et al.

Summary: The model proposed by the authors explains the rise and fall pattern of age-related diseases incidence by the accumulation of damaged cells, offering a potential treatment strategy to remove these cells and reduce incidence in old age. This approach could potentially increase healthspan by targeting a physiological mechanism related to senescent cells.

AGING CELL (2021)

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Article Clinical Neurology

A Multi-Step Model of Parkinson's Disease Pathogenesis

Campbell Le Heron et al.

Summary: The age-specific incidence of Parkinson's disease suggests a multistep pathogenic process, with an average of six steps before age 45 and eight steps after. The model supports theories that emphasize the role of environmental factors in driving sex differences in disease incidence.

MOVEMENT DISORDERS (2021)

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Article Clinical Neurology