期刊
MOVEMENT DISORDERS
卷 37, 期 6, 页码 1304-1309出版社
WILEY
DOI: 10.1002/mds.29010
关键词
Parkinson's disease; perivascular Virchow-Robin spaces; basal ganglia; white matter hyperintensities; ONDRI
资金
- Ontario Brain Institute - Ontario government
- Baycrest Foundation
- Bruyere Research Institute
- Centre for Addiction and Mental Health Foundation
- London Health Sciences Foundation
- McMaster University Faculty of Health Sciences
- Ottawa Brain and Mind Research Institute
- Queen's University Faculty of Health Sciences
- Thunder Bay Regional Health Sciences Centre
- University of Ottawa Faculty of Medicine
- Windsor/Essex County ALS Association
- Temerty Family Foundation
- Linda C. Campbell Foundation
- Dr. Sandra Black Centre for Brain Resilience and Recovery
This study showed that small BG-PVS are associated with motor and nonmotor aspects of experiences in daily living, while large BG-PVS are associated with motor symptoms and motor complications.
Background Although previously thought to be asymptomatic, recent studies have suggested that magnetic resonance imaging-visible perivascular spaces (PVS) in the basal ganglia (BG-PVS) of patients with Parkinson's disease (PD) may be markers of motor disability and cognitive decline. In addition, a pathogenic and risk profile difference between small (<= 3-mm diameter) and large (>3-mm diameter) PVS has been suggested. Objective The aim of this study was to examine associations between quantitative measures of large and small BG-PVS, global cognition, and motor/nonmotor features in a multicenter cohort of patients with PD. Methods We performed a cross-sectional study examining the association between large and small BG-PVS with Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Parts I-IV and cognition (Montreal Cognitive Assessment) in 133 patients with PD enrolled in the Ontario Neurodegenerative Disease Research Initiative study. Results Patients with PD with small BG-PVS demonstrated an association with MDS-UPDRS Parts I (P = 0.008) and II (both P = 0.02), whereas patients with large BG-PVS demonstrated an association with MDS-UPDRS Parts III (P < 0.0001) and IV (P < 0.001). BG-PVS were not correlated with cognition. Conclusions Small BG-PVS are associated with motor and nonmotor aspects of experiences in daily living, while large BG-PVS are associated with the motor symptoms and motor complications. (c) 2022 International Parkinson and Movement Disorder Society
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