期刊
MOLECULES
卷 27, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/molecules27103079
关键词
amphotericin B; curcumin; PLGA MPs; antifungal activity; biofilms
资金
- China Postdoctoral Science Foundation [2019M652851]
- Project of Education Department of Jilin Province [JJKH20210024KJ]
- Technology Project of Traditional Chinese Medicine Science of Jilin Province [2021174]
- National Natural Science Foundation of China [81972204]
- Natural Science Foundation of Guangdong Province [2019A1515011097]
- Innovation Program of Shenzhen [JCYJ20180508165208399]
- Science, the Technology Planning Project of Guangzhou [201904010089]
- State Key Lab of Respiratory Disease, Guangzhou Medical University [SKLRD-Z-202002]
- 111 Project from the Ministry of Education of China [D18010]
AMB/CM-PLGA MPs, co-loaded with AMB and CM, offer reduced hemolysis and nephrotoxicity compared to AMB alone. These MPs also exhibit better inhibitory effects on Candida albicans and improved therapeutic efficacy in vivo.
Amphotericin B (AMB) is an antifungal drug used for serious fungal infections. However, AMB has adverse reactions such as nephrotoxicity, which limit the clinical application of AMB alone or in combination with other antifungal drugs. Nano or micro drug delivery systems (DDS) have been proven to be effective in reducing the toxic and side effects of drugs. Further, the combination of AMB with other compounds with antifungal activity, such as curcumin (CM), may enhance the synergistic effects. Herein, AMB and CM were co-loaded into porous poly (lactic-co-glycolic acid) (PLGA) microparticles (MPs) to prepare AMB/CM-PLGA MPs. The AMB/CM-PLGA MPs showed a remarkably reduced hemolysis (62.2 +/- 0.6%) compared to AMB (80.9 +/- 1.1%). The nephrotoxicity of AMB/CM-PLGA MPs is significantly lower than that of AMB. In vitro, AMB/CM-PLGA MPs had better inhibitory effects on the adhesion and biofilm formation of Candida albicans compared with AMB. Experiments on mice infected with C. albicans showed that AMB/CM-PLGA MPs have a better therapeutic effect than AMB in vivo. In summary, AMB/CM-PLGA MPs may be a novel and promising therapeutic candidate for fungal infection.
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