期刊
MOLECULES
卷 27, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/molecules27051495
关键词
SWATH; NaAsO2; dictyophora; polysaccharides; neurotoxicity
资金
- National Natural Science Foundation of China [81860560, U1812403-6-2-4]
- Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions [2021SHIBS0003]
- Guizhou Science Combined Support [[2021]134]
- Science and Technology Fund Project of Guizhou Provincial Health Commission [gzwjkj2020-1-188]
Arsenic is an important toxic element in the environment, and its effects on the brain are still limitedly studied. This study used proteomics to reveal the mechanism of arsenic neurotoxicity in rats and the protective effect of dictyophora polysaccharide.
Arsenic (As) is one of the most important toxic elements in the natural environment. Currently, although the assessment of the potential health risks of chronic arsenic poisoning has received great attention, the research on the effects of arsenic on the brain is still limited. It has been reported that dictyophora polysaccharide (DIP), a common bioactive natural compound found in dietary plants, could reduce arsenic toxicity. Following behavioral research, comparative proteomics was performed to explore the molecular mechanism of arsenic toxicity to the hippocampi of SD (Sprague Dawley) rats and the protective effect of DIP. The results showed that exposure to arsenic impaired the spatial learning and memory ability of SD rats, while DIP treatment improved both the arsenic-exposed rats. Proteomic analysis showed that arsenic exposure dysregulated the expression of energy metabolism, apoptosis, synapse, neuron, and mitochondria related proteins in the hippocampi of arsenic-exposed rats. However, DIP treatment reversed or restored the expression levels of these proteins, thereby improving the spatial learning and memory ability of arsenic-exposed rats. This study is the first to use high-throughput proteomics to reveal the mechanism of arsenic neurotoxicity in rats as well as the protective mechanism of DIP against arsenic neurotoxicity.
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