Stereoselective Synthesis of β-Glycinamide Ribonucleotide

A diastereoselective synthesis of the beta-anomer of glycinamide ribonucleotide (beta-GAR) has been developed. The synthesis was accomplished in nine steps from D-ribose and occurred in 5% overall yield. The route provided material on the multi-milligram scale. The synthetic beta-GAR formed was remarkably resistant to anomerization both in solution and as a solid.

Automated summary

A diastereoselective synthesis of the beta-anomer of glycinamide ribonucleotide (beta-GAR) has been developed with a high overall yield. The synthetic beta-GAR demonstrated remarkable resistance to anomerization in both solution and solid state.