期刊
MOLECULES
卷 27, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/molecules27072233
关键词
natural products; one-pot reactions; alkaloids; Masuda borylation-Suzuki coupling
资金
- Deutsche Forschungsgemeinschaft [GRK 2158]
- Fonds der Chemischen Industrie
In this study, a new synthetic method was developed for the concise synthesis of various marine indole alkaloids. The method demonstrated high yields and simplicity.
N-Protected 3-iodoindoles were reacted with (di)azine halides in a sequentially Pd-catalyzed one-pot fashion, i.e., by Masuda borylation-Suzuki coupling (MBSC) sequence. This methodology was successfully applied to the concise syntheses of marine indole alkaloids meridianin C, D, F, and G, as well as to the bisindole alkaloid scalaridine A, which were obtained in moderate to excellent yield.
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