4.6 Review

The Signaling Pathways and Targets of Natural Compounds from Traditional Chinese Medicine in Treating Ischemic Stroke

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Neurosciences

Research progress of natural products for the treatment of ischemic stroke

Jiaxin Li et al.

Summary: Stroke is a major cause of death and disability globally, and its incidence rate is increasing. Natural products have been used in traditional medicine and show potential in the treatment of stroke. This article reviews the neuroprotective effects of 33 natural compounds, some of which have potential as clinical treatments for ischemic stroke.

JOURNAL OF INTEGRATIVE NEUROSCIENCE (2022)

Article Chemistry, Medicinal

Cardamonin attenuates cerebral ischemia/reperfusion injury by activating the HIF-1 alpha/VEGFA pathway

Hongzao Ni et al.

Summary: Cardamonin protects against damage and increased permeability caused by ischemic stroke by activating the HIF-1α/VEGFA pathway.

PHYTOTHERAPY RESEARCH (2022)

Review Pharmacology & Pharmacy

Recent Advances in Chinese Herbal Medicine for Cerebral Ischemic Reperfusion Injury

Ping Huang et al.

Summary: Cerebral ischemic reperfusion injury (CI/RI) is a critical factor leading to poor prognosis in patients with ischemic stroke. Chinese herbal medicine (CHM) has been identified as a potential treatment for CI/RI due to its abundant resources, good efficacy, and few side effects. This paper investigates the latest drug discoveries and advancements in CI/RI, provides an overview of relevant CHM, and summarizes the pathophysiology of CI/RI. Additionally, it discusses the protective effect and mechanism of CHM, as well as the limitations and challenges faced in its application.

FRONTIERS IN PHARMACOLOGY (2022)

Article Peripheral Vascular Disease

Skullcapflavone II protects neuronal damage in cerebral ischemic rats via inhibiting NF-κB and promoting angiogenesis

Danpeng Zhao et al.

Summary: This study found that Skullcapflavone II (SCP) has a protective effect on cerebral ischemia/reperfusion injury by reducing cerebral edema, infarct volume, neurological deficits, oxidative stress, inflammation, and increasing angiogenesis.

MICROVASCULAR RESEARCH (2022)

Article Plant Sciences

Diosgenin revealed potential effect against cerebral ischemia reperfusion through HIKESHI/HSP70/NF-KB anti-inflammatory axis

Xinxin Zhang et al.

Summary: This study identified a novel signaling pathway HIKESHI/HSP70/NF-kappa B associated with DIO-treated I/R, which may serve as therapeutic targets or drugs with potential implications for the treatment of I/R in clinic.

PHYTOMEDICINE (2022)

Review Chemistry, Applied

The genus Turbinaria: chemical and pharmacological diversity

Mohammed I. Rushdi et al.

Summary: Compounds isolated from the Genus Turbinaria have promising therapeutic potentials in various aspects such as anti-inflammatory, immunostimulatory, cardioprotective, and hypolipidemic effects.

NATURAL PRODUCT RESEARCH (2021)

Article Toxicology

Ephedrine attenuates cerebral ischemia/reperfusion injury in rats through NF-κB signaling pathway

Chanhong Shi et al.

Summary: Ephedrine alleviates cerebral ischemia/reperfusion injury by reducing inflammatory responses, decreasing autophagy and apoptosis, and reducing protein expression of p-NF-kappa B.

HUMAN & EXPERIMENTAL TOXICOLOGY (2021)

Article Immunology

Syringin exerts neuroprotective effects in a rat model of cerebral ischemia through the FOXO3a/NF-κB pathway

Junyi Tan et al.

Summary: Syringin demonstrated a protective effect against brain ischemia/reperfusion injury in rats, reducing inflammation and acting through the FOXO3a/NF-kappa B pathway.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Article Medicine, Research & Experimental

Artesunate attenuates inflammatory injury and inhibits the NF-κB pathway in a mouse model of cerebral ischemia

Ying Liu et al.

Summary: Artesunate may protect against cerebral ischemia injury by reducing inflammation, decreasing infarct size, and improving neurological deficits.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2021)

Article Cell Biology

Palmatine Protects against Cerebral Ischemia/Reperfusion Injury by Activation of the AMPK/Nrf2 Pathway

Chaoliang Tang et al.

Summary: Palmatine (PAL), a natural isoquinoline alkaloid, exhibits extensive biological and pharmaceutical activities, including antioxidative stress, anti-inflammatory, antitumor effects. PAL treatment shows protective effects against ischemic stroke and cerebral ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and neuronal apoptosis, possibly through the activation of the AMP-activated protein kinase (AMPK)/nuclear factor E2-related factor 2 (Nrf2) pathway.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Plant Sciences

Oxymatrine improves blood-brain barrier integrity after cerebral ischemia-reperfusion injury by downregulating CAV1 and MMP9 expression

Yu Jiao-Yan et al.

Summary: Oxymatrine (OMT) has protective effects on neurological function and reduces blood-brain barrier permeability. OMT protects against ischemia-reperfusion injury through modulation of cellular damage and tight junction protein expression levels.

PHYTOMEDICINE (2021)

Article Pharmacology & Pharmacy

Tanshinone IIA Protects Against Cerebral Ischemia Reperfusion Injury by Regulating Microglial Activation and Polarization via NF-κB Pathway

Zhibing Song et al.

Summary: Tanshinone IIA has been shown to provide neuroprotection in a rat model of cerebral ischemia, reducing infarction volume and improving neuronal injuries. It exerts its anti-neuroinflammatory effects by modulating microglial M1/M2 polarization through the NF-kappa B signaling pathway.

FRONTIERS IN PHARMACOLOGY (2021)

Article Neurosciences

The bidirectional role of the JAK2/STAT3 signaling pathway and related mechanisms in cerebral ischemia-reperfusion injury

Yi Zhong et al.

Summary: The JAK2/STAT3 signaling pathway plays a crucial role in ischemic stroke by regulating inflammatory response, apoptosis, oxidative stress, and angiogenesis.

EXPERIMENTAL NEUROLOGY (2021)

Article Pharmacology & Pharmacy

Machine learning enables discovery of Gentianine targeting TLR4/NF-κB pathway to repair ischemic stroke injury

Na Wang et al.

Summary: The study found that Gentianine can suppress inflammatory responses by inhibiting the TLR4/NF-kappa B signaling pathway, making it a potential agent for anti-ischemic stroke treatment.

PHARMACOLOGICAL RESEARCH (2021)

Article Pharmacology & Pharmacy

Baicalin Attenuates Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury by Modulating the BDNF-TrkB/PI3K/Akt and MAPK/Erk1/2 Signaling Axes in Neuron-Astrocyte Cocultures

Changxiang Li et al.

Summary: This study showed that baicalin protects neurons from oxidative stress, inflammation, and apoptosis by promoting astrocytes to release more BDNF. The neuroprotective effect is mainly mediated through the BDNF-TrkB pathway and downstream signaling regulators PI3K/Akt and MAPK/ERK1/2.

FRONTIERS IN PHARMACOLOGY (2021)

Article Medicine, Research & Experimental

HIF-1α attenuates neuronal apoptosis by upregulating EPO expression following cerebral ischemia-reperfusion injury in a rat MCAO model

Jun Li et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2020)

Review Medicine, Research & Experimental

ERK/MAPK signalling pathway and tumorigenesis

Yan-Jun Guo et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

Article Biotechnology & Applied Microbiology

Taraxasterol protects hippocampal neurons from oxygen-glucose deprivation-induced injury through activation of Nrf2 signalling pathway

Yun He et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2020)

Review Neurosciences

Targeting Oxidative Stress and Inflammation to Prevent Ischemia-Reperfusion Injury

Liquan Wu et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2020)

Review Biochemistry & Molecular Biology

Hepatoprotective effect of plant polysaccharides from natural resources: A review of the mechanisms and structure-activity relationship

Jialin Qu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Article Biochemistry & Molecular Biology

Neuroprotective Effects of Emodin against Ischemia/Reperfusion Injury through Activating ERK-1/2 Signaling Pathway

Stephen Wan Leung et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Neurosciences

MAPK: A Key Player in the Development and Progression of Stroke

Yangmin Zheng et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2020)

Article Medicine, Research & Experimental

Effect of matrine on JAK2/STAT3 signaling pathway and brain protection in rats with cerebral ischemia-reperfusion

Jixing Chen et al.

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE (2020)

Review Biochemistry & Molecular Biology

Metabolism and pharmacological activities of the natural health-benefiting compound diosmin

Yizhou Zheng et al.

FOOD & FUNCTION (2020)

Article Cardiac & Cardiovascular Systems

Heart Disease and Stroke Statistics-2019 Update A Report From the American Heart Association

Emelia J. Benjamin et al.

CIRCULATION (2019)

Article Biochemistry & Molecular Biology

Neuroprotective Effects of Ginsenosides against Cerebral Ischemia

Zhekang Cheng et al.

MOLECULES (2019)

Article Medicine, Research & Experimental

Effect of -patchoulene on cerebral ischemia-reperfusion injury and the TLR4/NF-B signaling pathway

Fu-Bo Zhang et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2019)

Review Pharmacology & Pharmacy

Critical Role of Nrf2 in Experimental Ischemic Stroke

Lei Liu et al.

FRONTIERS IN PHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Transcriptome Analysis of Clinopodium chinense (Benth.) O. Kuntze and Identification of Genes Involved in Triterpenoid Saponin Biosynthesis

Yuanyuan Shi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Biochemistry & Molecular Biology

Recent Advances in Biotransformation of Saponins

Yi He et al.

MOLECULES (2019)

Review Cell Biology

Akt-ing Up Just About Everywhere: Compartment-Specific Akt Activation and Function in Receptor Tyrosine Kinase Signaling

Michael G. Sugiyama et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Review Spectroscopy

Mass spectrometry-driven drug discovery for development of herbal medicine

Aihua Zhang et al.

MASS SPECTROMETRY REVIEWS (2018)

Article Biochemistry & Molecular Biology

Neuroprotective Effect of Curcumin Against Cerebral Ischemia-Reperfusion Via Mediating Autophagy and Inflammation

Lifa Huang et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2018)

Review Biochemistry & Molecular Biology

SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection

Nunzia D'Onofrio et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

Review Pharmacology & Pharmacy

Antitumor Activity of Polysaccharides: An Overview

Ling Chen et al.

CURRENT DRUG TARGETS (2018)

Article Biochemical Research Methods

High-throughput lipidomics characterize key lipid molecules as potential therapeutic targets of Kaixinsan protects against Alzheimer's disease in APP/ PS1 transgenic mice

Hong-Lei Gao et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2018)

Review Cell Biology

Nrf2 at the heart of oxidative stress and cardiac protection

Qin M. Chen et al.

PHYSIOLOGICAL GENOMICS (2018)

Article Biochemistry & Molecular Biology

Avocado Seed: A Comparative Study of Antioxidant Content and Capacity in Protecting Oil Models from Oxidation

Francisco J. Segovia et al.

MOLECULES (2018)

Article Pharmacology & Pharmacy

TLR4/NF-κB/Ceramide signaling contributes to Ox-LDL-induced calcification of human vascular smooth muscle cells

Yan Song et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2017)

Article Clinical Neurology

Protective effects of ginsenoside Rg1 against oxygen-glucose-deprivation-induced apoptosis in neural stem cells

Yiwen Li et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2017)

Article Medicine, Research & Experimental

Neuroprotective mechanisms of miR-124 activating PI3K/Akt signaling pathway in ischemic stroke

Changming wang et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2017)

Review Biochemistry & Molecular Biology

Mitochondrial composition and function under the control of hypoxia

Dominik C. Fuhrmann et al.

REDOX BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Osthole prevents cerebral ischemia-reperfusion injury via the Notch signaling pathway

Junhong Guan et al.

BIOCHEMISTRY AND CELL BIOLOGY (2017)

Article Cardiac & Cardiovascular Systems

Ac-SDKP suppresses TNF-α-induced ICAM-1 expression in endothelial cells via inhibition of IκB kinase and NF-κB activation

Liping Zhu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2016)

Review Medicine, Research & Experimental

The PI3K/AKT Pathway as a Target for Cancer Treatment

Ingrid A. Mayer et al.

ANNUAL REVIEW OF MEDICINE, VOL 67 (2016)

Editorial Material Public, Environmental & Occupational Health

Stroke: a global response is needed

Walter Johnson et al.

BULLETIN OF THE WORLD HEALTH ORGANIZATION (2016)

Article Biochemistry & Molecular Biology

Cytotoxic Alkaloids from the Stem of Xylopia laevigata

Leociley R. A. Menezes et al.

MOLECULES (2016)

Review Oncology

Epidermal growth factor receptor and notch signaling in non-small-cell lung cancer

Joanna Pancewicz-Wojtkiewicz

CANCER MEDICINE (2016)

Review Medicine, General & Internal

The contribution of NF-κB signalling to immune regulation and tolerance

Myrthe A. M. van Delft et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Biochemistry & Molecular Biology

Structural basis of Keap1 interactions with Nrf2

Peter Canning et al.

FREE RADICAL BIOLOGY AND MEDICINE (2015)

Article Biochemistry & Molecular Biology

Anti-diabetic properties of Momordica charantia L. polysaccharide in alloxan-induced diabetic mice

Xin Xu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2015)

Review Cell Biology

Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models

Danielle R. Bruns et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2015)

Article Multidisciplinary Sciences

Acetylation of NDPK-D Regulates Its Subcellular Localization and Cell Survival

Yuki Fujita et al.

PLOS ONE (2015)

Review Biochemistry & Molecular Biology

Molecular basis of MAP kinase regulation

Wolfgang Peti et al.

PROTEIN SCIENCE (2013)

Article Medicine, Research & Experimental

Mechanism of focal cerebral ischemic tolerance in rats with ischemic preconditioning involves MyD88-and TRIF-dependent pathways

Han Li et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2013)

Review Immunology

Mitogen-activated protein kinases in innate immunity

J. Simon C. Arthur et al.

NATURE REVIEWS IMMUNOLOGY (2013)

Review Pharmacology & Pharmacy

NF-κB as a Target for Modulating Inflammatory Responses

Chiara Gasparini et al.

CURRENT PHARMACEUTICAL DESIGN (2012)

Review Cardiac & Cardiovascular Systems

Multiple Facets of NF-κB in the Heart To Be or Not to NF-κB

Joseph W. Gordon et al.

CIRCULATION RESEARCH (2011)

Article Chemistry, Medicinal

Evaluation of human neutrophil elastase inhibitory effect of iridoid glycosides from Hedyotis diffusa

Guang-Hua Xu et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)

Article Biochemistry & Molecular Biology

Time course of upregulation of inflammatory mediators in the hemorrhagic brain in rats: Correlation with brain edema

He Wu et al.

NEUROCHEMISTRY INTERNATIONAL (2010)

Review Biochemistry & Molecular Biology

Molecular Mechanisms of Nrf2-Mediated Antioxidant Response

Wenge Li et al.

MOLECULAR CARCINOGENESIS (2009)

Review Biochemistry & Molecular Biology

MAP kinases and the control of nuclear events

A. G. Turjanski et al.

ONCOGENE (2007)

Article Biochemistry & Molecular Biology

JAK2 and STAT3 activation contributes to neuronal damage following transient focal cerebral ischemia

Irawan Satriotomo et al.

JOURNAL OF NEUROCHEMISTRY (2006)

Article Endocrinology & Metabolism

Alteration of MAP kinase pathways after transient forebrain ischemia

BR Hu et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2000)