期刊
MOLECULES
卷 27, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/molecules27051742
关键词
cancer immunotherapy; fructan; FT-IR; mass spectrometry; young green barley
资金
- Green Ways International, Prague, Czech Republic [713/11/2019]
The water extract from young green barley (YGB) has been found to have a beneficial impact on natural killer (NK) cells' ability to recognize and eliminate human colon cancer cells. This extract also exhibits a direct anticancer effect. The mixture of oligosaccharides found in the extract consists mainly of glucose and fructose, with a small amount of mannose and galactose.
Young green barley (YGB) water extract has revealed a beneficial impact on natural killer (NK) cells' ability to recognize and eliminate human colon cancer cells, without any side effects for normal colon epithelial cells. The direct anticancer effect of the tested compounds has been also shown. The mixture of oligosaccharides found in this extract was characterized by chemical analyses and via FT-IR spectroscopy and MALDI-TOF MS techniques. The YGB preparation contained 26.9% of proteins and 64.2% of sugars, mostly glucose (54.7%) and fructose (42.7%), with a small amount of mannose (2.6%) and galactose (less than 0.5%). Mass spectrometry analysis of YGB has shown that fructose oligomers contained from 3 to 19 sugar units. The number of fructans was estimated to be about 10.2% of the dry weight basis of YGB. The presented results suggest the beneficial effect of the consumption of preparations based on young barley on the human body, in the field of colon cancer prevention.
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