期刊
MOLECULES
卷 27, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/molecules27092920
关键词
polyhedral boron hydrides; closo-dodecaborate; cobalt bis(dicarbollide); curcumin; click reaction; antibacterial activity; Staphylococcus aureus; Enterococcus faecalis
资金
- Russian Science Foundation [20-73-00228]
- Russian Science Foundation [20-73-00228] Funding Source: Russian Science Foundation
A series of novel conjugates of cobalt bis(dicarbollide) and closo-dodecaborate with curcumin were synthesized and tested for antibacterial activity. One of the conjugates exhibited better activity against Gram-positive microorganisms.
A series of novel conjugates of cobalt bis(dicarbollide) and closo-dodecaborate with curcumin were synthesized by copper(I)-catalyzed azide-alkyne cycloaddition. These conjugates were tested for antibacterial activity. It was shown that all derivatives are active when exposed to Bacillus cereus ATCC 10702 and are not active against Gram-negative microorganisms and Candida albicans at the maximum studied concentration of 1000 mg/L. The conjugate of alkynyl-curcumin with azide synthesized from the tetrahydropyran derivative of cobalt bis(dicarbollide) exhibited activity against Gram-positive microorganisms: Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212 and the clinical isolate MRSA 17, that surpassed curcumin by 2-4 times.
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