☆ 4.6 Article

Anti-Inflammatory Effects of Spiramycin in LPS-Activated RAW 264.7 Macrophages

MOLECULES (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Biochemistry & Molecular Biology

Recent advances in drug repurposing using machine learning

Fabio Urbina et al.

Summary: Drug repurposing involves finding new uses for existing and approved drugs. Recent developments in this field have utilized machine learning and other computational approaches, with applications in cancer, Alzheimer's disease, and COVID-19 treatment.

CURRENT OPINION IN CHEMICAL BIOLOGY (2021)

添加到收藏夹

Review Dermatology

Redirecting drug repositioning to discover innovative cosmeceuticals

Georgia Sotiropoulou et al.

Summary: Skin appearance plays a crucial role in self-esteem and quality of life, leading to a huge market for skin care products. Cosmeceuticals, as a hybrid category between cosmetics and pharmaceuticals, are designed to improve skin health and appearance. Recent advances in using drug repositioning approaches have shown the potential to accelerate the discovery of targeted cosmeceuticals, with a focus on promoting skin health by exploiting druggable protein targets implicated in various diseases.

EXPERIMENTAL DERMATOLOGY (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Etoricoxib may inhibit cytokine storm to treat COVID-19

Ruo Wang

Summary: The global spread of COVID-19 has caused an unprecedented disaster, with cytokine storm playing a critical role in the development of acute and severe illness. In the absence of specific drugs and vaccines, repositioning existing drugs like etoricoxib to inhibit cytokine storm may be a potential treatment for COVID-19.

MEDICAL HYPOTHESES (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Drug-Repositioning Approaches Based on Medical and Life Science Databases

Yoshito Zamami et al.

Summary: Drug repositioning is a strategy that utilizes existing drugs for different diseases to reduce cost and time in drug development. Traditional method involves identifying candidate drugs through basic research, while recent approach uses information from medical and life science databases for translational research bridging the gap between basic research and clinical application.

FRONTIERS IN PHARMACOLOGY (2021)

添加到收藏夹

Editorial Material Pharmacology & Pharmacy

Is drug repurposing really the future of drug discovery or is new innovation truly the way forward?

Carmen Gil et al.

EXPERT OPINION ON DRUG DISCOVERY (2021)

添加到收藏夹

Article Microbiology

Pharmacokinetic/Pharmacodynamic Modeling of Spiramycin against Mycoplasma synoviae in Chickens

Sara T. Elazab et al.

Summary: The study assessed the pharmacokinetics/pharmacodynamics and tissue residues of spiramycin in chickens, providing recommendations for oral dosage and withdrawal period against M. synoviae infection in chickens.

PATHOGENS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Anti-Inflammatory Effects of 6-Methylcoumarin in LPS-Stimulated RAW 264.7 Macrophages via Regulation of MAPK and NF-κB Signaling Pathways

Jin-Kyu Kang et al.

Summary: The study demonstrated that 6-MC reduced the levels of nitric oxide and prostaglandin E-2 without causing cytotoxicity, and also decreased the expression of pro-inflammatory cytokines in a concentration-dependent manner in LPS-stimulated cells. Western blot results showed that 6-MC treatment decreased the protein levels of iNOS and COX-2 induced by LPS, while mechanistic studies revealed its inhibitory effects on the MAPK and NF-kappa B pathways.

MOLECULES (2021)

添加到收藏夹

Article Infectious Diseases

In vitro activity of non-antibiotic drugs against Staphylococcus aureus clinical strains

Natalie K. Boyd et al.

Summary: The study found that four non-antibiotic drugs demonstrated varying degrees of in vitro activity against clinical isolates of Staphylococcus aureus, with ebselen showing the most potent effect.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2021)

添加到收藏夹

Review Medicine, Research & Experimental

A fresh look at the role of spiramycin in preventing a neglected disease: meta-analyses of observational studies

Jose G. Montoya et al.

Summary: The meta-analysis of 33 studies showed a significant reduction in mother-to-child transmission rates of Toxoplasma gondii following spiramycin treatment in pregnant women.

EUROPEAN JOURNAL OF MEDICAL RESEARCH (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

The use of real-world data in drug repurposing

Kyungsoo Park

Summary: Drug repurposing involves finding new uses for existing drugs, which can significantly reduce costs and time to market. Real world data (RWD) is increasingly utilized to support drug development, as it better represents actual patterns of drug treatment and outcomes in real world settings.

TRANSLATIONAL AND CLINICAL PHARMACOLOGY (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Drug repositioning: a brief overview

Jean-Pierre Jourdan et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

4-Hydroxy-7-Methoxycoumarin Inhibits Inflammation in LPS-activated RAW264.7 Macrophages by Suppressing NF-kappa B and MAPK Activation

Jin Kyu Kang et al.

MOLECULES (2020)

添加到收藏夹

Article Chemistry, Applied

In vitro immunomodulatory effects of human milk oligosaccharides on murine macrophage RAW264.7 cells

Weiyue Zhang et al.

CARBOHYDRATE POLYMERS (2019)

添加到收藏夹

Article Infectious Diseases

Spiramycin and azithromycin, safe for administration to children, exert antiviral activity against enterovirus A71 in vitro and in vivo

Shinuan Zeng et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2019)

添加到收藏夹

Article Genetics & Heredity

Anti-inflammatory effect of Calycosin glycoside on lipopolysaccharide-induced inflammatory responses in RAW 264.7 cells

Lin Dong et al.

GENE (2018)

添加到收藏夹

Article Plant Sciences

Anti-inflammatory sesquiterpenoids from the Traditional Chinese Medicine Salvia plebeia: Regulates pro-inflammatory mediators through inhibition of NF-kappa B and Erk1/2 signaling pathways in LPS-induced Raw264.7 cells

Yi-Hong Zou et al.

JOURNAL OF ETHNOPHARMACOLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Anti-Obesity Effects of Spiramycin In Vitro and In Vivo

Mun Ock Kim et al.

PLOS ONE (2016)

添加到收藏夹

Article Microbiology

Spiramycin resistance in human periodontitis microbiota

Thomas E. Rams et al.

ANAEROBE (2011)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.